Trichuris suis ova therapy in inflammatory bowel disease: A meta-analysis

Medicine
Xing HuangMeng-Hua Zhu

Abstract

In recent years, Trichuris suis ova (TSO) therapy in inflammatory bowel disease (IBD) has attracted much attention. However, efficacy and safety of TSO therapy are still not well described. The aim of the study was to perform a meta-analysis to assess the effectiveness of TSO therapy in IBD. PubMed, Embase, Web of Science, ClinicalTrials.gov, and Cochrane Library were searched from inception to August 2017. Only randomized, double-blind, placebo-controlled trials (RCTs) were included. The pooled estimate rates were performed by meta-analysis and reported according to the standard Cochrane guidelines and the PRISMA statement. In ulcerative colitis study (3 RCTs, n = 74), the induced rates of clinical remission and clinical response were 10.8% (4/37) and 53.8% (21/39) in TSO group, while 6.7% (2/30) and 29.0% (9/31) in placebo group (all P > .26). Twenty-two (9/41) percent of patients in TSO group experienced at least 1 adverse event compared with 27.3% (9/33) of placebo [relative ratio (RR) 0.75, 95% confidence interval (95% CI) 0.17-3.27]. In Crohn disease study (3 RCTs, n = 538), 40.7% (74/182) of patients in TSO group achieved clinical remission compared with 42.9% (90/210) of placebo (RR 0.95, 95% CI 0.75-1.20); 45.9% (141/3...Continue Reading

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Citations

May 30, 2020·Nature Reviews. Disease Primers·Kathryn J ElsePhilip J Cooper
Aug 17, 2019·Alimentary Pharmacology & Therapeutics·Tamara MogilevskiPeter R Gibson
Mar 25, 2021·Parasitology·Jesica HayonBin Zhan
Mar 2, 2021·Annual Review of Immunology·Bonnie DouglasDe'Broski R Herbert
Oct 21, 2020·European Journal of Gastroenterology & Hepatology·Sebastian KjærgaardMark Berner-Hansen
Jun 24, 2021·Journal of Crohn's & Colitis·Tim RaineGarret Cullen

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NCT03079700
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