Triclosan inhibits sodium lauryl sulphate-induced changes in expression of cytokeratin genes in hamster cheek pouch epithelium

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
J H Baert, R J Veys

Abstract

Triclosan is known to reduce the untoward side effects of sodium lauryl sulphate (SLS). The aim of the present study was to determine whether triclosan can inhibit SLS-induced changes in expression of cytokeratin (CK) genes in hamster cheek pouch epithelium. With a hybridohistochemical technique, using specific human cRNA probes, hamster CK mRNAs were identified by immunological detection of heterologous hybrids. In contrast to application of SLS-containing paste, application of paste containing SLS together with triclosan produced no marked changes in expression and distribution patterns of CK mRNAs, compared to the normal cheek pouch epithelium. Therefore, we may accept that triclosan inhibits the effect of SLS on CK gene expression. However, the mechanism of this protection remains elusive. Conversely, the epithelial hyperplasia induced by application of SLS was histologically identical to that induced by application of SLS and triclosan. This suggests that the changes in CK gene expression identified in the present study are not a simple consequence of epithelial hyperplasia, but rather are specific to the irritating agent. Establishment of the fact that SLS may influence gene expression, and that this may be prevented by t...Continue Reading

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Citations

Jul 21, 2012·Organic Letters·Sukhendu NandiAndre Mayer
Feb 21, 2019·Acta Odontologica Scandinavica·Antonija TadinDavor Zeljezic

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