Triclosan-loaded chitosan as antibacterial agent for adhesive resin

Journal of Dentistry
Ana Helena Schauenberg MachadoFabrício Mezzomo Collares

Abstract

The aim of this study was to formulate and to evaluate the immediate and long-term physical, chemical and antibacterial properties of an experimental adhesive resin with chitosan or triclosan-loaded chitosan. Chitosan, triclosan and triclosan-loaded chitosan were evaluated for scanning electron microscopy (SEM) and micro-Raman spectroscopy. An experimental adhesive resin was formulated with methacrylate monomers and photoinitiators. Chitosan or triclosan-loaded chitosan were added at 2 (GQ2% and GQT2%) or 5 (GQ5% and GQT5%) wt.% in the base resin. The base resin was used as control (GCTRL). The adhesives were evaluated for degree of conversion (DC), Knoop hardness (KHN), softening in solvent (ΔKHN), immediate and long-term microtensile bond-strength (μ-TBS) and antibacterial activity. SEM indicated triclosan sticks and chitosan porosity. Triclosan-loaded chitosan presented structures on chitosan. Micro-Raman indicated no chemical interaction between chitosan and triclosan. There was no difference among groups for DC (p > 0.05). Initial KHN ranged from 17.36 (±1.56) to 20.38 (±1.72), with higher value for GQT5% compared to GCTRL (p < 0.05). GCTRL presented the lowest ΔKHN% (p < 0.05). There were no differences in the immediate o...Continue Reading

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Citations

Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio
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Sep 15, 2020·Journal of Dentistry·Islam Mahmoud BendaryVicente Castelo Branco Leitune

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