Triclosan-loaded poloxamine micelles for enhanced topical antibacterial activity against biofilm

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Diego A ChiappettaAlejandro Sosnik

Abstract

Our research group is interested in the study of different technological approaches to treat hospital biofilm as a means to constrain nosocomial-acquired infections. The present work investigated the effect of the incorporation of the antibacterial agent triclosan (TS) into polymeric micelles of poloxamine T1107 (MW=15 kDa, 70 wt% PEO). The aggregation phenomenon was primarily investigated by means of Critical Micellar Concentration in a broad range of pH. Then, the effect of the polymer concentration on the micellar size was evaluated by Dynamic Light Scattering. Solubility levels increased up to 4 orders of magnitude. The drug inclusion affected the micellization, resulting in size increase and micellar fusion. This phenomenon was only apparent in TS-saturated systems. TS-loaded aggregates proved to be active in vitro against a broad spectrum of bacteria but more importantly, also against two representative clinical pathogens: methicilin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF). While the former was sensitive to even very low TS levels attainable in poloxamine-free aqueous media, the later was inhibited only when exposed to higher drug levels affordable exclusively using an ...Continue Reading

References

Jun 1, 1996·American Journal of Infection Control·H N Bhargava, P A Leonard
Sep 8, 1998·Journal of Biomedical Materials Research·Y H An, R J Friedman
Jun 6, 2000·Advanced Drug Delivery Reviews·E S Ron, L E Bromberg
Sep 22, 2000·Trends in Biotechnology·S M Moghimi, A C Hunter
Mar 17, 2001·Advanced Drug Delivery Reviews·K KataokaY Nagasaki
Jul 21, 2001·Lancet·P S Stewart, J W Costerton
Oct 18, 2001·International Journal of Pharmaceutics·J K ArmstrongS A Leharne
Jun 6, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·Alexander V Kabanov, Valery Yu Alakhov
Sep 3, 2003·The Journal of Antimicrobial Chemotherapy·Sabine Favre-BontéChristian Van Delden
Apr 6, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Edward J BottoneSaul Hymes
Sep 29, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wolfgang Witte
Mar 22, 2005·International Journal of Pharmaceutics·Michael CrothersColin Booth
Apr 9, 2005·International Journal of Pharmaceutics·E Piñón-SegundoD Quintanar-Guerrero
Jul 19, 2005·Biomaterials·Alejandro Sosnik, Michael V Sefton
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Dec 20, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Doron SteinbergMichael Friedman
Dec 24, 2005·Expert Opinion on Drug Delivery·Hamidreza Montazeri Aliabadi, Afsaneh Lavasanifar
Jan 10, 2006·Biomacromolecules·Alejandro Sosnik, Michael V Sefton
Mar 11, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Francesca MaestrelliMaria José Alonso
Jul 4, 2006·Journal of Biomedical Materials Research. Part a·Erin E MacKintoshJames M Anderson
Sep 22, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kirk A OverhoffRobert O Williams
Nov 25, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Carmen Alvarez-LorenzoAngel Concheiro
Dec 16, 2006·Current Pharmaceutical Design·S R Croy, G S Kwon
May 8, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A Chiappetta, Alejandro Sosnik

❮ Previous
Next ❯

Citations

Mar 29, 2013·World Journal of Microbiology & Biotechnology·Marco FidaleoRoberto Lavecchia
Aug 26, 2011·Journal of the Royal Society, Interface·Marcela A MorettonAlejandro Sosnik
Aug 29, 2012·Photochemistry and Photobiology·María C García ViorJosefina Awruch
Dec 7, 2010·Nanomedicine·Carmen Alvarez-LorenzoAlejandro Sosnik
Jul 1, 2010·Therapeutic Delivery·Evren H GokceEliana B Souto
Mar 5, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Diego A ChiappettaAlejandro Sosnik
Dec 28, 2010·Biomaterials·Diego A ChiappettaAlejandro Sosnik
May 25, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A ChiappettaAlejandro Sosnik
Mar 9, 2018·International Journal of Molecular Sciences·Ana Rey-Rico, Magali Cucchiarini
Jan 29, 2011·Macromolecular Bioscience·Renata VyhnalkovaTheo van de Ven
Sep 15, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maximiliano CagelDiego A Chiappetta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Jaime Gonzalez-LopezAngel Concheiro
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Diego A Chiappetta, Alejandro Sosnik
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Carmen Alvarez-LorenzoAngel Concheiro
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Diego A ChiappettaAlejandro Sosnik
© 2021 Meta ULC. All rights reserved