PMID: 9533404Apr 9, 1998Paper

Tricresyl phosphate inhibits the formation of axon-like processes and disrupts neurofilaments in cultured mouse N2a and rat PC12 cells

Neuroscience Letters
J FlaskosA J Hargreaves

Abstract

Tricresyl phosphate (1 microg/ml) inhibited the outgrowth of axon-like processes in mouse N2a neuroblastoma and rat PC12 pheochromocytoma cell lines induced to differentiate by serum withdrawal and nerve growth factor addition, respectively. By contrast, it had no effect on the outgrowth of processes by rat C6 glioma cells induced to differentiate with sodium butyrate. The effect on axon outgrowth in the two neuronal cell lines correlated with altered distribution of neurofilament proteins, as determined by indirect immunofluorescence with monoclonal antibody RMd09. Western blots of neuronal cell extracts probed with the same antibody revealed decreased cross-reactivity after exposure to tricresyl phosphate. The results suggest that tricresyl phosphate has a selective effect on neuronal cell differentiation, which involves impaired axon outgrowth, reduced levels of the neurofilament heavy chain and disruption of the neurofilament network.

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Citations

Jul 19, 2002·Journal of Neuroscience Research·Terrence TownMike Mullan
Jul 18, 2008·Archives of Toxicology·Erasmia SidiropoulouZerai Woldehiwet
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M SachanaA J Hargreaves
Jan 23, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M SachanaA J Hargreaves
Jun 15, 2000·Journal of Neurochemistry·L A De GirolamoA J Hargreaves
Sep 10, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vanessa HausherrNicole Schöbel
Jan 1, 2005·Toxicology Mechanisms and Methods·Magdalini SachanaAlan J Hargreaves
Jan 29, 2016·Biochemical and Biophysical Research Communications·Hiroyoshi TsuchiyaTaka-Aki Koshimizu
Jul 15, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E SidiropoulouZ Woldehiwet
Apr 18, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M SachanaA J Hargreaves
Sep 13, 2015·Neurotoxicology and Teratology·Hester S Hendriks, Remco H S Westerink
Jun 8, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M LawtonA J Hargreaves
Jan 24, 2007·Toxicology and Applied Pharmacology·J FlaskosA J Hargreaves
Jan 15, 2014·Basic & Clinical Pharmacology & Toxicology·Magdalini SachanaAlan J Hargreaves
Dec 21, 2010·Toxicology Letters·Erasmia SidiropoulouZerai Woldehiwet
Dec 15, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen LauC Vyvyan Howard
Oct 18, 2019·Traffic·Prerana BhanOliver I Wagner
Mar 27, 2020·Frontiers in Molecular Neuroscience·Chang LiuFuwu Wang
Aug 16, 2006·Molecular and Cellular Biochemistry·Ping-An Chang, Yi-Jun Wu

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