Tricyclic and related drugs for nocturnal enuresis in children

The Cochrane Database of Systematic Reviews
Patrina H Y CaldwellWicky C F Wong

Abstract

Enuresis (bedwetting) affects up to 20% of five year-olds and 2% of adults. Although spontaneous remission often occurs, the social, emotional and psychological costs can be great. Tricyclics have been used to treat enuresis since the 1960s. To assess the effects of tricyclic and related drugs compared with other interventions for treating children with enuresis. We searched the Cochrane Incontinence Group Specialised Trials Register (containing trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE in process, ClinicalTrials.gov, WHO ICTRP and handsearching of journals and conference proceedings), on 30 November 2015, and reference lists of relevant articles. We included all randomised and quasi-randomised trials comparing a tricyclic or related drug with another intervention for treating enuresis. We also included combination therapies that included tricyclics. We excluded trials for treating daytime wetting. Two review authors independently assessed the quality of the eligible trials, and extracted data. We settled differences by discussion with a third review author. Sixty-four trials met the inclusion criteria, involving 4071 children. The quality of many trials was poor, with...Continue Reading

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Citations

Nov 8, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patrina H Y CaldwellGail Nankivell
May 5, 2020·The Cochrane Database of Systematic Reviews·Patrina Hy CaldwellPremala Sureshkumar
Jan 3, 2020·Journal of Child and Adolescent Psychopharmacology·Aysha LukmanjiScott B Patten
Jun 5, 2019·Deutsches Ärzteblatt International·Alexander von Gontard, Eberhard Kuwertz-Bröking
Apr 7, 2021·Journal of Pediatric Urology·Sonja Izquierdo Riis MeyerSøren Rittig

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