Jan 1, 1976

Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications

Clinical Toxicology
T C Brown

Abstract

Tricyclic antidepressant overdosage may be complicated by cardiac arrhythmias, which were sometimes difficult to treat prior to the use of sodium bicarbonate. Experiments have been done with several antiarrhythmics in an attempt to define the optimum treatment. Sodium bicarbonate proved the most effective experimentally and this supports our clinical experience. Physostigmine is a useful second drug, having beneficial effects against arrhythmias and central nervous system manifestations of toxicity. Practolol, although reversing the arrhythmias, tends to cause hypotension. Other drugs tried were less effective.

  • References18
  • Citations28

References

  • References18
  • Citations28

Mentioned in this Paper

Circulatory System
Practolol
Anti-Arrhythmia Agents
Entire Central Nervous System
Metals
Sodium Bicarbonate
Amitriptyline Hydrochloride
Tricyclic Antidepressant [EPC]
Cardiac Depressants
Blood Circulation

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