To review poisoning with tricyclic antidepressants. English language literature search using Australian Medlars Service (1977-1989), manual search of journals and review of bibliographies in identified articles. Approximately 250 articles, abstracts and book chapters were selected for analysis. The literature was reviewed and 93 articles were selected as representative of important advances. The major features of overdose are neurological, cardiac, respiratory and anticholinergic. Life-threatening complications develop within six hours of overdose or not at all. All patients seen within six hours of overdose should have their stomachs emptied. All patients should receive activated charcoal. Coma, convulsions, respiratory depression and hypotension are treated with standard resuscitation techniques and drugs. Treat patients with significant cardiotoxicity or cardiac arrest with alkalinisation by sodium bicarbonate or hyperventilation, aiming for an arterial pH of 7.45-7.55. Lignocaine is used for ventricular arrhythmias. Other antiarrhythmic drugs are contraindicated (Class 1A, Class 1C), potentially lethal (Class II), of no benefit (phenytoin) or of unproven efficacy (Class III and Class IV). Physostigmine has no role at all. H...Continue Reading
Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications
Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness
The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations
Ventilation and acid-base changes in deep coma due to barbiturate or tricyclic antidepressant poisoning
Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness
Beneficial effect of norepinephrine in the treatment of circulatory shock caused by tricyclic antidepressant overdose
Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants
Sodium bicarbonate and hyperventilation in treating an infant with severe overdose of tricyclic antidepressant
Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion
Management of the cardiovascular complications of tricyclic antidepressant poisoning : role of sodium bicarbonate
Temporary cardiac pacemaker in the treatment of junctional rhythm and hypotension due to imipramine intoxication
Screening of antidepressant activity and estimation of quercetin from Coccinia indica using TLC densitometry
Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine
Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement
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