Tricyclic antidepressant toxicity treated with massive sodium bicarbonate

The American Journal of Emergency Medicine
Jessica E PierogTracey Helmick

Abstract

Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006). Early recognition and aggressive treatment are necessary for patient survival.

References

Aug 19, 1999·The American Journal of Emergency Medicine·R A Harrigan, W J Brady

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Citations

Feb 9, 2012·Drug and Chemical Toxicology·Mohammadali EmamhadiMarzieh Hassanijirdehi
Jul 15, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Rebecca E Bruccoleri, Michele M Burns
Apr 16, 2019·Journal of Pharmacy Practice·Pansy ElsamadisiIfeoma Mary Eche
Jun 1, 2021·Critical Care Clinics·Lara PriscoFrancesca Rubulotta

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