Tricyclic antidepressants and cognitive decline

Psychosomatics
Laura Jean Podewils, Constantine G Lyketsos

Abstract

In this study, we sought to determine the cross-sectional and longitudinal relations of tricyclic antidepressant (TCA) use to cognitive function and cognitive change in a population-based sample of adults (n=1,488). Sociodemographic information, TCA use, and baseline scores on the Mini-Mental State Exam (MMSE) were determined in the initial two waves of the study. At wave 3, participants repeated the MMSE; the prospective relation was assessed for change between waves 2 and 3 (median 11.5 years). These findings failed to support the concept that TCA use is related to concurrent measurable cognitive deficits, and TCA use does not appear to significantly compromise memory over a substantial time span.

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Citations

Aug 19, 2011·Applied Neuropsychology·Åsa HammarMari Strand
Nov 14, 2013·Journal of Clinical and Experimental Neuropsychology·Guy G PotterDavid C Steffens
Feb 1, 2006·Acta Neuropsychiatrica·Jacqueline J M H StrikJelle Jolles
Sep 16, 2011·Harvard Review of Psychiatry·Joseph Stoklosa, Dost Öngür
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Apr 1, 2006·Pediatric Clinics of North America·Keith Henry, Carson R Harris
May 10, 2015·La Presse médicale·Anne-Sophie Lemaire-HurtelAlain G Verstraete
Feb 12, 2009·Journal of the American Geriatrics Society·Rollin M WrightUNKNOWN Health, Aging and Body Composition Study
Jan 25, 2012·International Journal of Geriatric Psychiatry·Guy G PotterDavid C Steffens
Aug 28, 2015·International Journal of Geriatric Psychiatry·Guy G PotterDavid C Steffens
Feb 24, 2015·International Journal of Geriatric Psychiatry·Joseph M DzierzewskiDavid C Steffens
Oct 16, 2014·International Journal of Geriatric Psychiatry·Guy G PotterDavid C Steffens
Aug 5, 2014·Zeitschrift für Gerontologie und Geriatrie·M GogolA Simm
Nov 16, 2007·Journal of Geriatric Psychiatry and Neurology·John O Brooks, Jennifer C Hoblyn

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