Existing data suggests dramatic efficacy for all tested tricyclics in disorders involving spontaneous panic attacks; moderate efficacy for clomipramine but not other tricyclics in obsessive-compulsive patients; possible, but as yet not well established, tricyclic efficacy in generalized anxiety; and lack of efficacy in simple phobias. Further studies in all DSM-III Anxiety Disorders are both warranted and required to answer the nosological, pathophysiological and treatment questions raised by these findings.
Successful treatment of severe anxiety attacks with tricyclic antidepressants: a potential mechanism of action
Tricyclic antidepressants in obsessive-compulsive disorder: antiobsessional or antidepressant agents? II
Doxepin and diazepam in general practice and hospital clinic neurotic patients: A collaborative controlled study
Lack of efficacy of a new antidepressant (bupropion) in the treatment of panic disorder with phobias
Clomipramine and exposure for chronic obsessive-compulsive rituals: III. Two year follow-up and further findings
The Galway Study of Panic Disorder. II: Changes in some peripheral markers of noradrenergic and serotonergic function in DSM III-R panic disorder
Antidepressant treatments in children and adolescents: II. Anxiety, physical, and behavioral disorders
Breathing retraining, exposure and a combination of both, in the treatment of panic disorder with agoraphobia
BDNF-TRKB signaling system of the dorsal periaqueductal gray matter is implicated in the panicolytic-like effect of antidepressant drugs
Enhanced reactivity of 5-HT1A receptors in the rat dorsal periaqueductal gray matter after chronic treatment with fluoxetine and sertraline: evidence from the elevated T-maze
Treatment of panic disorder in older adults: a pilot study comparison of alprazolam, imipramine, and placebo
Neural correlates of pathological gamblers preference for immediate rewards during the iowa gambling task: an fMRI study
Implications of peripheral muscular and anatomical development for the acquisition of lingual control for speech production: a review
Experiencing core symptoms of anxiety and unipolar mood disorders in late adolescence predicts disorder onset in early adulthood.
Pharmacologic treatments effective in both generalized anxiety disorder and major depressive disorder: clinical and theoretical implications
Role of 5-HT1A and 5-HT2C receptors of the dorsal periaqueductal gray in the anxiety- and panic-modulating effects of antidepressants in rats.
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