PMID: 7932548Sep 30, 1994Paper

Tridentate ligands containing the SNS donor atom set as a novel backbone for the development of technetium brain-imaging agents

Journal of Medicinal Chemistry
S. G. MastrostamatisEfstratios Chiotellis

Abstract

In developing 99mTc complexes as potential brain-imaging agents, we investigated the coordination chemistry of ligands containing sulfur and nitrogen donor atoms with the general formula R-CH2CH2N(CH2CH2SH)2 (R = C2H5S, (C2H5)2N). These ligands act as tridentate SNS chelates to the TcO3+ core, leaving open one coordination site cis to the oxo group. In reactions with the highly reactive [99TcOCl4]- precursor, this vacancy was occupied by a chlorine atom. When the ligands reacted in the presence of 4-methoxythiophenol, using 99Tc(V)-gluconate as precursor, the vacancy was filled with 4-methoxythiophenol, which acted as coligand. Thus neutral mixed ligand complexes of the general formula [TcO((SCH2CH2)2NCH2CH2R)X], where X = Cl or 4-methoxythiophenol, were synthesized. The complexes were characterized by UV-vis, IR, 1H NMR, crystallographic, and elemental analyses. The crystal structures of 3a (R = C2H5S, X = Cl) and 4b (R = (C2H5)2N, X = 4-methoxythiophenol) demonstrated that the coordination geometry is trigonal bipyramidal with the N1 and Cl or S3 occupying the apical positions and the basal plane defined by the S1 and S2 of the tridentate ligand and the oxo group. The complexes 4a(99mTc) (R = C2H5S, X = 4-methoxythiophenol) a...Continue Reading

Citations

Jun 5, 2002·Annals of Nuclear Medicine·Yasushi Arano
Aug 1, 2000·Inorganica Chimica Acta·Frank J FemiaJon Zubieta
Jun 1, 2000·Journal of Inorganic Biochemistry·M PelecanouC I Stassinopoulou
Jun 6, 2000·Advanced Drug Delivery Reviews·Y Arano
Feb 24, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A ReyA Leon
Aug 28, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Xin-hong DuanXue-bin Wang
Nov 17, 2001·Nuclear Medicine and Biology·C TsoukalasE Chiotellis
Feb 2, 2002·Nuclear Medicine and Biology·A LeónE Chiotellis
Jan 27, 2004·Nuclear Medicine and Biology·Célia FernandesIsabel Santos
Jun 6, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huafan HuangTaiwei Chu
Jun 16, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Dionysia Papagiannopoulou
Dec 26, 2001·Chemical Reviews·S Liu, D S Edwards
Apr 16, 2002·Inorganic Chemistry·Corneliu BudaPeter S Shenkin
Jan 20, 1999·Bioconjugate Chemistry·M B Skaddan, J A Katzenellenbogen
Jun 6, 1997·Journal of Medicinal Chemistry·P C MeltzerB K Madras
Nov 5, 1997·Bioconjugate Chemistry·S LiuJ A Barrett
Dec 4, 1996·Inorganic Chemistry·M. S. PapadopoulosE. Chiotellis
Jul 4, 2006·Inorganic Chemistry·Aris ChiotellisEfstratios Chiotellis
Jul 1, 1996·Bioconjugate Chemistry·S MeegallaH F Kung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.