PMID: 6401801Feb 1, 1983Paper

Trifluoperazine inhibits 45Ca2+ uptake and catecholamine secretion and synthesis in adrenal medullary cells

Journal of Neurochemistry
A WadaH Kobayashi

Abstract

In isolated adrenal medullary cells, carbamylcholine and high K+ cause the calcium-dependent secretion of catecholamines with a simultaneous increase in the synthesis of 14C-catecholamines from [14C]tyrosine. In these cells, trifluoperazine, a selective antagonist of calmodulin, inhibited both the secretion and synthesis of catecholamines. The stimulatory effect of carbamylcholine was inhibited to a greater extent than that of high K+. The inhibitory effect of trifluoperazine on carbamylcholine-evoked secretion of catecholamines was not overcome by an increase in either carbamylcholine or calcium concentration, showing that inhibition by trifluoperazine occurs by a mechanism distinct from competitive antagonism at the cholinergic receptor and from direct inactivation of calcium channels. Doses of trifluoperazine that inhibited catecholamine secretion and synthesis also inhibited the uptake of radioactive calcium by the cells. These results suggest that trifluoperazine inhibits the secretion and synthesis of catecholamines mainly due to its inhibition of calcium uptake. Trifluoperazine seems to inhibit calcium uptake by uncoupling the linkage between calcium uptake by uncoupling the linkage between cholinergic receptor stimulati...Continue Reading

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Citations

Sep 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·S SakuraiN Yanagihara
Apr 1, 1985·Agents and Actions·N Chakravarty, E H Nielsen
Sep 14, 1984·Biochimica Et Biophysica Acta·R D Burgoyne, K M Norman
Feb 13, 1992·European Journal of Pharmacology·J M TrifaróA Rodríguez Del Castillo
Nov 27, 2002·European Journal of Pharmacology·Kenzo KudoTakeshi Kashimoto
Nov 21, 1996·European Journal of Pharmacology·A OsajimaA Kuroiwa
Jun 1, 1987·Acta Physiologica Scandinavica·K SletholtK M Gautvik
Oct 30, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyo-Jeong LimDong-Yoon Lim
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W E Khalbuss, R Wondergem
Jun 25, 1984·Biochimica Et Biophysica Acta·R D Burgoyne

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