PMID: 6971882Apr 1, 1981Paper

Trigeminal deafferentation and ingestive behavior in rats

Journal of Comparative and Physiological Psychology
M G Miller

Abstract

For studying the role of orosensory input in the control of ingestive behavior, rats were subjected to varying degrees of trigeminal deafferentation. Somatosensory branches that convey touch, temperature, and pain from the oral cavity were sectioned selectively, and innervation of the muscles of mastication and taste afferents were left intact. Severe intake deficits were produced, which included aphagia, adipsia, and prolonged hypophagia accompanied by a corresponding decrease in body weight. The deficits were proportional to the extent of deafferentation and were most severe when upper and lower portions of the mouth were affected. Although somatosensory impairment affected the organization of the consummatory response, all rats could bite, chew, and lick. Analysis of feeding patterns of minimally (mandibular) deafferented rats showed that the animals compensated for the consummatory inefficiency by increasing meal duration but failed to initiate meals at the normal rate, thus keeping food intake below normal levels. These results suggest that oral somatosensory input is critical for the mechanisms that regulate ingestive behavior.

Citations

Mar 1, 1985·Physiology & Behavior·M G Miller, J F Teates
Jan 1, 1987·Physiology & Behavior·Y MiyaokaT Shingai
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·H P ZeiglerM G Miller
Jan 1, 1987·Behavioural Brain Research·K C Berridge, J C Fentress
Jan 31, 1994·Behavioural Brain Research·B G KleinB Kraje
Apr 1, 1995·Journal of Oral Rehabilitation·I HaraS Nakahara
Sep 1, 1990·The International Journal of Neuroscience·S WeinsteinC Weinstein
Nov 26, 2011·Journal of Dental Research·A BraudY Boucher
Nov 1, 1988·Neuroscience and Behavioral Physiology·V S LushchekinN G Gladkovich
Aug 28, 2019·International Journal of Environmental Research and Public Health·Chen-Yi LiangAndy Yen-Tung Teng
May 10, 1985·Science·K C Berridge, J C Fentress

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