Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Mohammed A AlhelalTheoharis C Theoharides

Abstract

The nervous system contributes to the pathophysiology of allergic and inflammatory diseases, including oral inflammation. Mast cells (MCs) are involved in their pathogenesis through proinflammatory mediator release. To investigate the effect of trigeminal nerve (TN) stimulation compared with sham operation on MC activation and oral vascular permeability in the gingiva, palate, buccal mucosa, and tongue of the rat and to examine the possible role of substance P using rats treated with capsaicin as neonates to deplete substance P. Six male Sprague-Dawley rats (250 g) were anesthetized and injected intravenously with Evans Blue (EB). Six other rats were injected neonatally with capsaicin (n = 3) or solvent (n = 3) and then injected with EB when they reached 250 g. The mandibular branch of the TN was stimulated for 1 minute (n = 3), and the remaining rats (n = 3) were subjected to sham operation. The ipsilateral and contralateral sides of the mouth were examined for EB extravasation, and tissue sections were removed for light and electron microscopy. TN stimulation resulted in EB extravasation in the ipsilateral side compared with the contralateral side or the ipsilateral side of sham-operated rats. Significant degranulation of MCs...Continue Reading

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Citations

May 6, 2015·European Journal of Pharmacology·Theoharis C TheoharidesIsaac Melamed
May 6, 2016·Frontiers in Immunology·Andrea I LoewendorfMike Harrington
Mar 7, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mitchell H Grayson
Sep 22, 2016·Chinese Journal of Integrative Medicine·Bo ChenHui-Min Calista Lim
Mar 28, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Ning-Cen LiYi Guo
Jun 24, 2019·Journal of Neuroscience Methods·Aaron DingleAaron J Suminski

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