PMID: 8946342Nov 6, 1996Paper

Trigeminally-mediated alteration of cardiorespiratory rhythms during nasal application of carbon dioxide in the rat

Journal of the Autonomic Nervous System
P YavariW Michael Panneton

Abstract

Stimulation of the upper respiratory tract with air-borne irritants can result in dramatic alterations of cardiorespiratory rhythms that include apnea, bradycardia and selective peripheral vasoconstriction. Since carbon dioxide can stimulate receptors in the nasal passages, we wanted to determine if this odorless gas can induce the same autonomic changes as air-borne irritants. Passing 100% carbon dioxide through the nasal passages of rats anesthetized with chloralose-urethane produced apnea, a vagally-mediated bradycardia and a sympathetically-mediated increase in mean arterial blood pressure. Application of atropine blocked the bradycardia without affecting respiratory or blood pressure changes, while injection of prazosin eliminated blood pressure responses but did not affect heart rate or apnea. There were no significant autonomic responses to nasal application of 10, 25 or 50% carbon dioxide. The responses were mediated through the trigeminal innervation of the nasal mucosa since they could be blocked when the anesthetic procaine was applied to the nasal cavity. We conclude that these cardiorespiratory responses are due to stimulation of trigeminal nociceptors located within the nasal mucosa.

References

Nov 11, 1992·The Journal of Physiology·D BartlettJ C Leiter
Oct 1, 1992·Journal of Applied Physiology·R E AlvaroH Rigatto
Apr 8, 1990·The Journal of Comparative Neurology·T E FingerW L Silver
Jun 1, 1991·The Journal of Comparative Neurology·W M Panneton
Sep 27, 1991·Brain Research·W M Panneton
Jan 1, 1991·Physiology & Behavior·S L YoungentobM M Mozell
Jul 1, 1990·Journal of the Autonomic Nervous System·W M Panneton
Jul 1, 1988·Electroencephalography and Clinical Neurophysiology·G Kobal, C Hummel
Nov 1, 1971·Comparative Biochemistry and Physiology. A, Comparative Physiology·A S Blix
Feb 1, 1972·The Journal of Physiology·J E James, M De Burgh Daly
Feb 1, 1969·The American Journal of Anatomy·N CaunaR T Wentges
Jun 1, 1993·American Journal of Diseases of Children·J S Kemp, B T Thach

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Citations

Aug 14, 2010·Journal of Applied Physiology·W Michael PannetonThomas E Dahms
Jan 23, 2010·Journal of Applied Physiology·W Michael PannetonRajko Juric
Feb 8, 2014·Journal of Forensic Sciences·Riccardo RossiFidelia Cascini
Dec 14, 2011·Respiratory Physiology & Neurobiology·W Michael PannetonD Wei Sun
Nov 16, 2013·Surgical Neurology International·Abbas AmirjamshidiSeyed Babak Ghasemi
Sep 26, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Elissa M HultSteven J Swoap
Jun 26, 2020·Frontiers in Neuroscience·W Michael Panneton, Qi Gan
Jan 19, 2019·Alternatives to Laboratory Animals : ATLA·Kathrin Herrmann, Paul Flecknell
Apr 6, 2019·Frontiers in Human Neuroscience·Mohammad SirousAndreas K Engel
Jul 9, 2021·Epilepsy & Behavior : E&B·Ranajay MandalPedro Irazoqui

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