Triggered propagated contractions in rat cardiac trabeculae. Inhibition by octanol and heptanol

Circulation Research
Y M ZhangHenk E D J Ter Keurs

Abstract

We studied the role of Ca2+ diffusion through gap junctions (GJs) in triggering and propagation of damage-induced contractions in cardiac muscle (TPCs) by evaluating effects of the GJ blockers octanol and heptanol (O&H) on TPCs. TPCs were elicited in trabeculae from rat right ventricle superfused with Krebs-Henseleit solution at 20 degrees C and 0.7 to 1.75 mmol/L [Ca2+]o. Force was measured with a silicon strain gauge; sarcomere length, by laser diffraction techniques. O&H (3 to 300 mumol/L) decreased force, propagation velocity, and triggering rate of TPCs in a dose-dependent manner. At 300 mumol/L, O&H decreased TPC force to 21.3% and 25.7%, propagation velocity to 15.4% and 13.0%, and triggering rate to 26.5% and 25.7%. At 300 mumol/L. O&H decreased twitch force to 79.0% and 77.8% and reduced time to 90% relaxation by 10% to 15%. Above 1 mmol/L, O&H abolished twitch force and TPCs. Image analysis of spread of the fluorescence profile of microinjected fura 2 salt revealed an effective diffusion coefficient for fura 2 of 21.0 +/- 3.3 microns2/s, which decreased to 12.6+/-1.5 and 7.07 +/- 0.7 microns2/s after 1 and 3 hours of exposure, respectively, to 100 mumol/L octanol, with a time constant of decline of 1.5+/-0.5 hours. Th...Continue Reading

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Citations

Oct 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Hendrick E D J ter Keurs
Mar 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Bradley N PlummerKenneth R Laurita
Mar 5, 2011·Pflügers Archiv : European journal of physiology·Henk E D J ter Keurs
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Oct 27, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahito MiuraBruno D Stuyvers
Apr 9, 2008·Progress in Biophysics and Molecular Biology·Henk E D J ter KeursAmir Landesberg
Aug 12, 2005·Annals of the New York Academy of Sciences·Henk E D J Ter KeursAmir Landesberg
Apr 1, 2008·Annals of the New York Academy of Sciences·Henk E D J Ter KeursAmir Landesberg
Jul 26, 2005·Pharmacology & Therapeutics·Penelope A Boyden, Henk ter Keurs
Jul 31, 2012·Progress in Biophysics and Molecular Biology·Aslak TveitoAndrew McCulloch
May 9, 2015·Journal of Molecular and Cellular Cardiology·Masahito MiuraChiyohiko Shindoh
Feb 22, 2005·Journal of Cardiovascular Electrophysiology·Suhua WuShien-Fong Lin
Apr 13, 2007·Physiological Reviews·Henk E D J Ter Keurs, Penelope A Boyden
Feb 24, 2001·Canadian Journal of Physiology and Pharmacology·M MiuraK Shirato
Feb 24, 2001·Canadian Journal of Physiology and Pharmacology·H E ter KeursM Miura
Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Chikaya OmichiJames N Weiss
Jun 18, 2004·Annals of the New York Academy of Sciences·Amir LandesbergSamuel Sideman
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Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S O SuadicaniD C Spray
Feb 3, 2005·Gastroenterology·Richard FischerDieter Häussinger

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