Triggering of renal tissue damage in the rabbit by IgG Fc-receptor-positive group A streptococci

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
L A BurovaA A Totolian

Abstract

Our previous studies have shown that streptococcal IgG Fc receptors (FcR) act to elicit circulating anti-IgG as well as renal glomerular deposition of IgG in rabbits immunized with group A streptococci (GAS). In order to study if other FcR-positive bacteria might have similar effects, rabbits were immunized with either group G streptococci (GGS; strain G148) or Staphylococcus aureus (strain Cowan I) for two periods of 8 and 6 weeks, respectively. At the end of immunization, circulating anti-IgG was found in 6 of 20 (30%) and 4 of 19 (21%) animals receiving G148 and Cowan I, respectively, compared to all 28 receiving FcR-positive GAS strains of types M1, M4, M15 or M22 (p < 0.05 for both comparisons); furthermore, anti-IgG appeared earlier and at higher levels in the GAS groups. Weak glomerular IgG deposits occurred in 5 out of 10 (50%) and 2 out of 8 (25%) animals immunized with G148 and Cowan I, respectively. In contrast, all 11 rabbits examined, given GAS of types M1 or M15, displayed heavy deposits. None of four control animals immunized with either of two FcR-negative strains, GAS type T27 or group B streptococci (GBS) type Ia, exhibited any renal IgG deposits or circulating anti-IgG. Renal tissue materials from rabbits imm...Continue Reading

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Citations

Jan 20, 2000·Biulleten' eksperimental'noĭ biologii i meditsiny·L A BurovaA A Totolian
Jan 29, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L A BurovaC Schalén
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Feb 13, 1999·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·L A BurovaC Schalen
Feb 22, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Larissa BurovaArtem Totolian
Nov 18, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Larissa BurovaArtem Totolian
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez

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