Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) Contributes to Bordetella pertussis Inflammatory Pathology.

Infection and Immunity
Danisha GallopCiaran Skerry

Abstract

Whooping cough (pertussis) is a severe pulmonary infectious disease caused by the bacteria Bordetella pertussis. Pertussis infects an estimated 24 million people annually, resulting in >150,000 deaths. The NIH placed pertussis on the list of emerging pathogens in 2015. Antibiotics are ineffective unless administered before the onset of the disease characteristic cough. Therefore, there is an urgent need for novel pertussis therapeutics. We have shown that sphingosine-1-phosphate receptor (S1PR) agonists reduce pertussis inflammation without increasing bacterial burden. Transcriptomic studies were performed to identify this mechanism and allow for the development of pertussis therapeutics that specifically target problematic inflammation without sacrificing bacterial control. These data suggested a role for triggering receptor expressed on myeloid cells-1 (TREM-1). TREM-1 cell surface receptor functions as an amplifier of inflammatory responses. Expression of TREM-1 is increased in response to bacterial infection of mucosal surfaces. In mice, B. pertussis infection results in Toll-like receptor 9 (TLR9)-dependent increased expression of TREM-1 and its associated cytokines. Interestingly, S1PR agonists dampen pulmonary inflammati...Continue Reading

References

Jul 20, 2007·The Cochrane Database of Systematic Reviews·S AltunaijiJ Massie
Aug 2, 2011·Seminars in Immunopathology·Hideru Obinata, Timothy Hla
Jan 8, 2014·Infection and Immunity·Yi-Tsung LinNien-Jung Chen
Jan 25, 2014·Journal of Lipid Research·Victoria A Blaho, Timothy Hla
Apr 23, 2014·The Journal of Pathology·Tijmen J HommesTom van der Poll
Dec 30, 2014·The Journal of Infectious Diseases·Ciaran SkerryNicholas H Carbonetti

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA493118

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR

Software Mentioned

Ingenuity Pathway Analysis
DESeq Bioconductor
Ingenuity Pathway Analysis ( IPA )
TopHat
GraphPad Prism
Ensembl
HTSeq

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.