Triggers of IgE class switching and allergy development

Annals of Medicine
Lars K Poulsen, Lone Hummelshoj

Abstract

The prevalence of immunoglobulin E (IgE)-mediated allergic diseases has been increasing for the last four decades. In this review determinants for an increased IgE synthesis are discussed on both an epidemiological and on an immunological level with special emphasis on the differentiation of the B cell to an IgE-producing plasma cell. Factors that favor an IgE immune response are low antigen doses and immunization via mucous membranes, but it is highly likely that other environmental factors besides exposure to the allergenic sources play a role. Important factors in the formation of the Thelper type 2 (Th2) T cell subset are the actions of thymic stromal lymphopoietin (TSLP) on dendritic cells and the OX40 ligand on CD4+ T cells. In order for a B lymphocyte to switch to IgE production it needs two signals provided by a Th2 cell in the form of the cytokines interleukin (IL-) 4/IL-13 and ligation of the CD40. In spite of a half-life of only a few days, there is evidence that the IgE response may last for years even without allergen stimulation. This is likely to be caused by long-lived IgE-producing plasma cells, and such cells may be difficult to target therapeutically thus emphasizing the need for more knowledge on preventable...Continue Reading

References

Oct 1, 1991·European Journal of Immunology·A RolinkF Melchers
Mar 12, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Bernfield, R D Sanderson
Feb 1, 1990·The Journal of Allergy and Clinical Immunology·M KlinkB Burrows
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J StavnezerE Severinson
Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Nov 28, 1985·Journal of Immunological Methods·S A Hudak, M R Kehry
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Sep 1, 1988·The Journal of Experimental Medicine·D A Lebman, R L Coffman
Apr 1, 1988·Molecular and Cellular Biology·S Lutzker, F W Alt
Apr 1, 1987·Immunological Reviews·M WablC M Steinberg
Oct 1, 1986·The Journal of Allergy and Clinical Immunology·R E Lindberg, C Arroyave
Jun 1, 1987·The Journal of Clinical Investigation·S C DreskinJ I Gallin
Nov 1, 1987·The Journal of Allergy and Clinical Immunology·M N Savliwala, R E Reisman
Apr 1, 1984·The Journal of Allergy and Clinical Immunology·V Holford-StrevensJ Manfreda
Jan 1, 1983·Acta Medica Scandinavica·R Hällgren, L Lundin
Feb 1, 1994·The Journal of Experimental Medicine·F BrièreJ Banchereau
Jun 1, 1993·Current Opinion in Immunology·G Kelsoe, B Zheng
Feb 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D HansenL K Poulsen
Oct 1, 1993·Clinical and Experimental Immunology·I HagelN Alvarez
Mar 1, 1996·The Journal of Experimental Medicine·F MalisanH Martinez-Valdez
Apr 1, 1996·Current Opinion in Immunology·J Stavnezer
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Szczeklik, J Jawień

❮ Previous
Next ❯

Citations

May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin FelicesLeslie J Berg
Nov 30, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tomer AvrahamBabak J Mehrara
Sep 30, 2009·International Archives of Allergy and Immunology·Vincent LombardiOmid Akbari
Jun 22, 2010·Environmental Health Perspectives·Philippe GrandjeanPál Weihe
Oct 21, 2009·World Journal of Gastroenterology : WJG·Sari AnthoniKaija-Leena Kolho
Mar 28, 2013·Journal of Toxicology·Jing LiuKari C Nadeau
Jan 1, 2008·Clinical & Developmental Immunology·Sergio RoaRogelio Gonzalez-Sarmiento
Jul 30, 2010·Ocular Immunology and Inflammation·Fan YangPing-Ping He
Jul 9, 2008·Scandinavian Journal of Primary Health Care·Sari AnthoniKaija-Leena Kolho
Apr 4, 2013·Leukemia & Lymphoma·Eric C VonderheidMarshall E Kadin
Aug 27, 2015·Inhalation Toxicology·W C WilliamsD M Lehmann
Apr 7, 2009·Expert Opinion on Biological Therapy·Motohiko SuzukiWeiping Min
Jun 1, 2012·Expert Opinion on Drug Discovery·Cailong FangSun Ying
May 15, 2012·Pulmonary Pharmacology & Therapeutics·Naresh Singh Redhu, Abdelilah S Gounni
Jun 21, 2011·The Journal of Allergy and Clinical Immunology·Janet RothersAnne L Wright
Oct 12, 2010·The Journal of Allergy and Clinical Immunology·Milena MilovanovicMargitta Worm
Jul 6, 2010·Pulmonary Pharmacology & Therapeutics·Z DiamantR Gerth van Wijk
Jul 3, 2010·The Journal of Investigative Dermatology·Milena MilovanovicMargitta Worm
Oct 18, 2008·Veterinary Immunology and Immunopathology·Bettina WagnerHollis N Erb
Feb 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D SpaziererT Jung
May 8, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L K Poulsen
May 21, 2009·Influenza and Other Respiratory Viruses·Tatiana ChirkovaLarisa Rudenko
Jan 30, 2009·Allergy·M SuzukiW-P Min
Feb 22, 2013·Journal of the Science of Food and Agriculture·Min-Jung BaeDong-Hwa Shon
Aug 13, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R-F ChenK D Yang
Jan 22, 2013·Veterinary Dermatology·Jolanta Klukowska-RötzlerJozef Janda
Mar 13, 2014·Journal of Medical Virology·Susana VazquezMaria Guadalupe Guzmán
Jul 23, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K M HewK C Nadeau
May 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jae Ho ChoiHye Gwang Jeong
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Min-Jung BaeDong-Hwa Shon
Jul 30, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Choong Gon KimSae Kwang Ku
Mar 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jae Ho ChoiHye Gwang Jeong
Oct 7, 2010·Expert Review of Respiratory Medicine·Kanami OriharaRedwan Moqbel
Jul 20, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hong-Jhang ChenWenchang Chiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.