Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

Cardiovascular Diabetology
Le WangJing-han Xu

Abstract

The triglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. Whether the TyG index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome (ACS) remains uncertain. The aim of this study was to investigate the prognostic value of the TyG index in patients with diabetes and ACS. A total of 2531 consecutive patients with diabetes who underwent coronary angiography for ACS were enrolled in this study. Patients were divided into tertiles according to their TyG index. The primary outcomes included the occurrence of major adverse cardiovascular events (MACEs), defined as all-cause death, non-fatal myocardial infarction and non-fatal stroke. The TyG index was calculated as the ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). The incidence of MACE increased with TyG index tertiles at a 3-year follow-up. The Kaplan-Meier curves showed significant differences in event-free survival rates among TyG index tertiles (P = 0.005). Multivariate Cox hazards regression analysis revealed that the TyG index was an independent predictor of MACE (95% CI 1.201-1.746; P < 0.001). T...Continue Reading

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Citations

Apr 10, 2021·Journal of Nutrition and Metabolism·Ricardo Rojas-HumpireSalomon Huancahuire-Vega
Jul 18, 2021·Cardiovascular Diabetology·Shouling WuYaohua Tian
Jul 24, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Juying LiLin Luo

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SAS
SPSS

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