Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Amani BesharaIlan Krause

Abstract

The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10 mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150 mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglyce...Continue Reading

Citations

Nov 25, 2017·Diabetes, Obesity & Metabolism·Stefano Del Prato, Robert Chilton
Nov 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Deqiang ZhengYan He
May 3, 2019·Science China. Life Sciences·Yao ChenRongqiao He
Jul 1, 2020·Diabetes/metabolism Research and Reviews·Wenning FuZuxun Lu
Dec 22, 2019·International Journal of Environmental Research and Public Health·Mohammed Abdullah Al Mansour
Jun 26, 2018·Current Diabetes Reports·Rona J Strawbridge, Natalie R van Zuydam
May 21, 2020·BMC Cardiovascular Disorders·Ali GhaemianMahmood Moosazadeh
Dec 22, 2020·International Journal of Hygiene and Environmental Health·Susanna D MitroMarinella Temprosa

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