Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China

Cardiovascular Diabetology
Tianpeng ZhengJianfei Song

Abstract

Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the correlations between serum levels of ANGPTL8 and subclinical atherosclerosis in type 2 diabetes. We measured serum ANGPTL8, blood lipids, blood glucose, common carotid artery Intima-Media Thickness (c-IMT) and calculated homeostasis model assessment of insulin resistance in (1) control subjects (n = 100), (2) type 2 diabetic patients without subclinical atherosclerosis (n = 100), and (3) type 2 diabetic patients with subclinical atherosclerosis (n = 100). Serum levels of ANGPTL8 and triglyceride (TG) were significantly increased in type 2 diabetic patients with subclinical atherosclerosis as compared with type 2 diabetic patients without subclinical atherosclerosis and control subjects (P < 0.001). ANGPTL8 was positively associated with age, TG, diabetes duration, and c-IMT in type 2 diabetes. Logistic regression analysis revealed that ANGPTL8 had higher odds of having subclinical atherosclerosis [odds ratio (OR) 2.90, 95% confidence interval (CI) 1.48-5.70, P = 0.002] in ...Continue Reading

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Citations

Jan 30, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Giuliano GenerosoMarcio S Bittencourt
Feb 23, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Tianpeng ZhengYujie Chen
Jul 18, 2020·Clinical Science·Lei ZhangXiao-Jing Zhang
May 19, 2020·British Journal of Biomedical Science·A AbdeltawabS M Zaied
Jun 26, 2021·Cardiovascular Diabetology·Huajie ZouXuefeng Yu
Aug 11, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Cunwei SunTianpeng Zheng

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Methods Mentioned

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