Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast
There is increasing evidence that fasting hypertriglyceridaemia identifies individuals who are at increased risk for coronary artery disease. It is probable that this reflects the effects of the smaller triglyceride-bearing lipoproteins. It may also reflect increased levels of postprandial lipoproteins. There is considerable theoretical and experimental evidence to support an atherogenic role for the smaller, triglyceride-rich postprandial lipoproteins. Cross-sectional studies in humans also indicate that those with coronary disease have increased levels of postprandial lipids, probably in the remnants of chylomicrons. Recently we have completed a study examining the progression of coronary atherosclerosis angiographically. The study showed that the progression was linearly related to the numbers of chylomicron remnant particles, as reflected by the quantity of apoB48 in Sf20-60 lipoproteins, in the postprandial circulation. This paper reviews these studies, the physiology of postprandial lipoprotein metabolism and the therapeutic implications of this information.
Delayed clearance of chylomicron remnants following vitamin-A-containing oral fat loads in broad-beta disease (type III hyperlipoproteinemia)
Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Münster study
Two different views of the relationship of hypertriglyceridemia to coronary heart disease. Implications for treatment
Increased removal of remnants of triglyceride-rich lipoproteins on a diet rich in polyunsaturated fatty acids
Cholesterol accumulation in J774 macrophages induced by triglyceride-rich lipoproteins. Comparison of very low density lipoprotein from subjects with type III, IV, and V hyperlipoproteinemias
Dissociation between postprandial lipemia and high density lipoprotein cholesterol concentrations in endurance-trained men
Postprandial plasma vitamin A metabolism in humans: a reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants
Postprandial lipoprotein metabolism in normal and obese subjects: comparison after the vitamin A fat-loading test
Utilisation of energy substrates in treadmill-exercised domestic fowl (Gallus gallus domesticus): blood plasma free fatty acids
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil
The chromogenicity and quantitation of apoB-100 and apoB-48 of human plasma lipoproteins on analytical SDS gel electrophoresis
The association of increased levels of intermediate-density lipoproteins with smoking and with coronary artery disease
Relative contribution of triglyceride-rich lipoprotein particle size and number to plasma triglyceride concentration
Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man
Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia
Postprandial lipemia. A key for the conversion of high density lipoprotein2 into high density lipoprotein3 by hepatic lipase
Transfer of plasma lipoprotein components and of plasma proteins into aortas of cholesterol-fed rabbits. Molecular size as a determinant of plasma lipoprotein influx
Is reverse cholesterol transport a misnomer for suggesting its role in the prevention of atheroma formation?
Ovariectomy decreases plasma triglyceride levels in analbuminaemic rats by lowering hepatic triglyceride secretion
Binding of prothrombin to chyle chylomicrons: effects of temperature and calcium ions, and role of surface phospholipids
Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma
Incremental area under response curve more accurately describes the triglyceride response to an oral fat load in both healthy and type 2 diabetic subjects
Conversion to mycophenolate mofetil in conjunction with stepwise withdrawal of cyclosporine in stable renal transplant recipients
Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia
Postprandial lipoprotein responses in hypertriglyceridemic subjects with and without cardiovascular disease
Post-prandial chylomicron response may be predicted by a single measurement of plasma apolipoprotein B48 in the fasting state
Association of vitamin K-dependent coagulation proteins and C4b binding protein with triglyceride-rich lipoproteins of human plasma
Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene
Adult-onset growth hormone deficiency: Relation of postprandial dyslipidemia to premature atherosclerosis
The NH2-terminal region of apolipoprotein B is sufficient for lipoprotein association with glycosaminoglycans.
Effects of Egg Consumption on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Effects of hydrochlorothiazide and propranolol treatment on chylomicron metabolism in hypertensive objects
ApoE, Lipids & Cholesterol
Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.
Atherosclerosis Disease Progression
Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.