PMID: 8251140Oct 1, 1993Paper

Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast

Annals of Medicine
G Steiner


There is increasing evidence that fasting hypertriglyceridaemia identifies individuals who are at increased risk for coronary artery disease. It is probable that this reflects the effects of the smaller triglyceride-bearing lipoproteins. It may also reflect increased levels of postprandial lipoproteins. There is considerable theoretical and experimental evidence to support an atherogenic role for the smaller, triglyceride-rich postprandial lipoproteins. Cross-sectional studies in humans also indicate that those with coronary disease have increased levels of postprandial lipids, probably in the remnants of chylomicrons. Recently we have completed a study examining the progression of coronary atherosclerosis angiographically. The study showed that the progression was linearly related to the numbers of chylomicron remnant particles, as reflected by the quantity of apoB48 in Sf20-60 lipoproteins, in the postprandial circulation. This paper reviews these studies, the physiology of postprandial lipoprotein metabolism and the therapeutic implications of this information.


Feb 5, 1976·The New England Journal of Medicine·G G RhoadsA Kagan
Sep 1, 1979·Circulation·D B Zilversmit
Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Jun 1, 1992·Stroke; a Journal of Cerebral Circulation·J E RyuJ R Crouse
Apr 1, 1991·European Journal of Clinical Investigation·P N DemackerA F Stalenhoef
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P H GrootL Havekes
Jul 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J C CohenS M Grundy
Dec 1, 1990·Atherosclerosis·H S SimpsonJ Shepherd
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G F LewisK S Polonsky
Aug 1, 1987·Metabolism: Clinical and Experimental·G SchlierfW Haberbosch
Dec 1, 1987·The Journal of Clinical Investigation·M S WeintraubJ L Breslow
Aug 1, 1986·American Heart Journal·W P Castelli
Jun 1, 1985·Metabolism: Clinical and Experimental·D E WilsonS C Horton
Jul 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M PoapstG Steiner
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J R PatschA M Gotto
Dec 1, 1984·The Journal of Clinical Investigation·J R PatschG Bengtsson-Olivecrona
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J P KaneH E Paulus
Jan 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S Stender, D B Zilversmit
Mar 1, 1994·Atherosclerosis·F KarpeA Hamsten
Jan 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·F KarpeA Hamsten
Jan 1, 1958·Transactions of the Association of American Physicians·M J ALBRINK, E B MANN
Sep 1, 1951·The American Journal of Medicine·H B JONESA V NICHOLS


Jan 15, 1996·Thrombosis Research·N XuA Nilsson
Mar 17, 2004·The Journal of Nutritional Biochemistry·I J Martins, T G Redgrave
Apr 21, 1999·Progress in Lipid Research·D A Chappell, J D Medh
Sep 18, 1998·Diabetes Research and Clinical Practice·G Steiner
Sep 28, 2002·Current Opinion in Lipidology·Spencer D ProctorJ C Mamo
Jun 30, 2009·Lipids in Health and Disease·Katherine K AnagnostopoulouDennis V Cokkinos
Mar 13, 2012·Maturitas·Martha ApostolopoulouChristos Savopoulos
Nov 16, 2010·The Canadian Journal of Cardiology·J David SpenceJean Davignon
Sep 23, 2008·Atherosclerosis·Edmond K KabagambeDonna K Arnett
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J J AgrenM Uusitupa
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·J David SpenceRobert A Hegele
Jul 29, 2006·Stroke; a Journal of Cerebral Circulation·J David Spence
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·T B TwicklerH P F Koppeschaar
Dec 18, 1998·The Journal of Biological Chemistry·I J GoldbergS Pillarisetti
Nov 8, 2017·Journal of the American College of Nutrition·Mohammad Hossein RouhaniFahimeh Haghighatdoost
Aug 11, 2005·Canadian Journal of Physiology and Pharmacology·Márcia M S BernikEder C R Quintão
Oct 13, 2019·Atherosclerosis·Ana Leon-AcuñaPablo Perez-Martinez

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved