Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes

Cell Reports
Maha F SajaMarina Botto

Abstract

Monocytes are heterogeneous effector cells involved in the maintenance and restoration of tissue integrity. However, their response to hyperlipidemia remains poorly understood. Here, we report that in the presence of elevated levels of triglyceride-rich lipoproteins, induced by administration of poloxamer 407, the blood numbers of non-classical Ly6C/Gr1(low) monocytes drop, while the number of bone marrow progenitors remains similar. We observed an increased crawling and retention of the Gr1(low) monocytes at the endothelial interface and a marked accumulation of CD68(+) macrophages in several organs. Hypertriglyceridemia was accompanied by an increased expression of tissue, and plasma CCL4 and blood Gr1(low) monocyte depletion involved a pertussis-toxin-sensitive receptor axis. Collectively, these findings demonstrate that a triglyceride-rich environment can alter blood monocyte distribution, promoting the extravasation of Gr1(low) cells. The behavior of these cells in response to dyslipidemia highlights the significant impact that high levels of triglyceride-rich lipoproteins may have on innate immune cells.

References

Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·M Maurer, E von Stebut
Jan 4, 2007·The Journal of Clinical Investigation·Frank TackeGwendalyn J Randolph
Jan 4, 2007·The Journal of Clinical Investigation·Filip K SwirskiMikael J Pittet
Jun 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shuhei YoshimotoYoshihiko Saito
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Nov 30, 2007·The Lancet Infectious Diseases·Jisun Oh, Robert A Hegele
Aug 20, 2008·The Journal of Experimental Medicine·Elin JaenssonWilliam W Agace
Nov 13, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sandy MosigHarald Funke
Aug 1, 2009·Arthritis and Rheumatism·Marie-Laure Santiago-RaberShozo Izui
Sep 23, 2009·Current Opinion in Hematology·Simon Yona, Steffen Jung
Apr 23, 2010·American Journal of Physiology. Renal Physiology·Kimihiko NakataniYoshihiko Saito
May 3, 2011·Cell·Kathryn J Moore, Ira Tabas
Jul 3, 2013·Nature Immunology·Jan HettingerMarkus Feuerer
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Greg A FosterEhrin J Armstrong
Aug 21, 2013·Nature Immunology·Nathanael J Spann, Christopher K Glass
Jan 17, 2014·Science Translational Medicine·Daniel R GettsNicholas J C King
May 24, 2014·Nature Reviews. Immunology·Florent Ginhoux, Steffen Jung
Jul 13, 2014·Cellular Immunology·Loems Ziegler-Heitbrock
Jul 19, 2014·Immunity·Slava EpelmanGwendalyn J Randolph
Nov 7, 2014·Cell Reports·Alexander V MisharinHarris Perlman

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Citations

Feb 13, 2016·European Heart Journal·Andrew J Murphy, Alan R Tall
Jan 13, 2017·Scientific Reports·Yiyuan PanJieshou Li
Mar 17, 2017·Nature Reviews. Cardiology·Mohammed Shamim RahmanKevin J Woollard
Sep 2, 2017·Circulation Research·Kevin J Woollard, Andrew J Murphy
Jan 4, 2018·Annals of Saudi Medicine·Khalid Al-RubeaanDhekra AlNaqeb
Aug 7, 2019·American Journal of Physiology. Endocrinology and Metabolism·Eline N KuipersMariëtte R Boon
Jul 12, 2017·The Journal of Clinical Investigation·Keehoon JungDai Fukumura

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Methods Mentioned

BETA
fluorescence-activated cell sorting
flow cytometry

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