Triglyceride to high-density lipoprotein cholesterol ratio predicts cardiovascular outcomes in prevalent dialysis patients

Medicine
Hung-Yuan ChenYu-Sen Peng

Abstract

Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, an indicator of atherogenic dyslipidemia, is a predictor of cardiovascular (CV) outcomes in the general population and has been correlated with atherosclerotic events. Whether the TG/HDL-C ratio can predict CV outcomes and survival in dialysis patients is unknown. We performed this prospective, observational cohort study and enrolled 602 dialysis patients (539 hemodialysis and 63 peritoneal dialysis) from a single center in Taiwan followed up for a median of 3.9 years. The outcomes were the occurrence of CV events, CV death, and all-cause mortality during follow-up. The association of baseline TG/HDL-C ratio with outcomes was explored with Cox regression models, which were adjusted for demographic parameters and inflammatory/nutritional markers. Overall, 203 of the patients experienced CV events and 169 patients died, of whom 104 died due to CV events. Two hundred fifty-four patients reached the composite CV outcome. Patients with higher TG/HDL-C levels (quintile 5) had a higher incidence of CV events (adjusted hazard ratio [HR] 2.03, 95% confidence interval [CI] 1.19-3.47), CV mortality (adjusted HR 1.91, 95% CI 1.07-3.99), composite CV outcome (adjusted HR...Continue Reading

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Citations

Sep 12, 2015·Metabolic Syndrome and Related Disorders·Eman Alefishat, Rana Abu Farha
Feb 15, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Tae Ik ChangHamid Moradi
Oct 17, 2018·International Journal of Endocrinology and Metabolism·Anawin Sanguankeo, Sikarin Upala
Nov 11, 2018·BMC Medical Genetics·Alicja E GrzegorzewskaPaweł P Jagodziński
Apr 10, 2021·Journal of Nutrition and Metabolism·Ricardo Rojas-HumpireSalomon Huancahuire-Vega

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Clinical Trials Mentioned

NCT01457625

Software Mentioned

SPSS

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