Trigoxyphins H and I: two new daphnane diterpenoids from Trigonostemon xyphophylloides

Bioorganic & Medicinal Chemistry Letters
Biao YangBing-Yan Zou

Abstract

Two new daphnane diterpenoids (1 and 2), together with four known analogues (3-6) were isolated from Trigonostemon xyphophylloides. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 were evaluated for in vitro cytotoxic activities against the SPCA-1 (human lung cancer) and BEL-7402 (human hepatocellular carcinoma) cancer cell lines. Trigoxyphin I (2) showed modest cytotoxicity against two tumor cell lines.

Citations

Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mélanie BourjotMarc Litaudon
Jun 26, 2018·Chemical Communications : Chem Comm·Jing FengBo Liu
Aug 15, 2013·Natural Product Reports·James R Hanson
May 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yue-Xian JinJing Zhang
Oct 1, 2020·Journal of Natural Products·Kouharu OtsukiKazuo Koike

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