Triiodothyronine acutely increases blood flow in the ventricles and kidneys of anesthesized rabbits

Thyroid : Official Journal of the American Thyroid Association
Koji KimuraHiroe Nakazawa

Abstract

Thyroid hormone (triiodothyronine [T(3)]) has various nongenomic effects, including alterations in glucose and fatty acid metabolism, augmentation of intracellular Ca(2+), enhancement of myocardial contractility, and vascular dilatation. However, its effect on regional blood flow remains to be established. We have measured the effect of T(3) on blood flow in major organs of anesthetized rabbits in vivo using the microsphere method. Under artificial respiration, nonradioactive microspheres (5 x 10(5)) labeled with barium were injected to measure blood flow at control level. Then, T(3) (50 microg/kg per milliliter) was administered and microspheres labeled with iodine (5 x 10(5)) were injected. The atria, ventricles, kidneys, and right upper limb were excised and their contents of microspheres were evaluated. Blood flow in the ventricles was significantly increased by T(3) (2.9 +/- 0.3 versus 3.4 +/- 0.3 mL/min per gram, vehicle versus T(3)). Similarly, blood flow in the kidneys was significantly higher after T(3) injection (4.3 +/- 0.5 versus 5.1 +/- 0.5 mL/min per, vehicle versus T(3)). The blood flow in the atria and skeletal muscles remained unchanged. These results indicate that the vasodilatory response to T(3) is not unifo...Continue Reading

References

Jul 1, 1991·The Annals of Thoracic Surgery·C M DykeD R Salter
Jul 1, 1993·The Annals of Thoracic Surgery·P J Davis, F B Davis
Jul 1, 1993·The Annals of Thoracic Surgery·K OjamaaI L Klein
Aug 1, 1993·Circulation Research·S C Dudley, C M Baumgarten
Apr 1, 1996·The Journal of Endocrinology·J SegalG Uretzky
Aug 26, 1998·Thyroid : Official Journal of the American Thyroid Association·K YonedaT Asahi
Feb 15, 2001·Journal of Molecular Endocrinology·C Wrutniak-CabelloG Cabello
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·Paul J Davis, Faith B Davis
Jan 16, 2003·The Journal of Physiology·Yong G WangStephen L Lipsius
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yong ZhuPeter Thomas
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lei LiJeffrey R Bender
Apr 6, 2004·Molecular and Cellular Endocrinology·J H Duncan BassettGraham R Williams
May 18, 2004·Nature Medicine·Thomas S ScanlanDavid K Grandy

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