Triiodothyronine exerts a trophic action on rat sensory neuron survival and neurite outgrowth through different pathways

The European Journal of Neuroscience
I B Walter

Abstract

Apart from several growth factors which play a crucial role in the survival and development of the central and peripheral nervous systems, thyroid hormones can affect different processes involved in the differentiation and maturation of neurons. The present study was initiated to determine whether triiodothyronine (T3) affects the survival and neurite outgrowth of primary sensory neurons in vitro. Dorsal root ganglia (DRG) from 19-day-old embryos or newborn rats were plated in explant or dissociated cell cultures. The effect of T3 on neuron survival was tested, either in mixed DRG cell cultures, where neurons grow with non-neuronal cells, or in neuron-enriched cultures where non-neuronal cells were eliminated at the outset. T3, in physiological concentrations, promoted the growth of neurons in mixed DRG cell cultures as well as in neuron-enriched cultures without added nerve growth factor (NGF). Since neuron survival in neuron-enriched cultures cannot be promoted by endogenous neurotrophic factors synthesized by non-neuronal cells, the increased number of surviving neurons was due to a direct trophic action of T3. Another trophic effect was revealed in this study: T3 sustained the neurite outgrowth of sensory neurons in DRG exp...Continue Reading

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Citations

Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Françoise CourtinMichel Pierre
Jan 1, 1997·American Journal of Human Biology : the Official Journal of the Human Biology Council·G LivshitsD Brunner
Apr 18, 2020·Developmental Neurobiology·Sara C Sousa, Mónica M Sousa
Aug 24, 1999·Journal of Neurobiology·I Barakat-Walter
Oct 3, 1998·The European Journal of Neuroscience·M L DoughtyJ Mariani

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