PMID: 2123790Nov 26, 1990Paper

Triiodothyronine increases rat apolipoprotein A-I synthesis and alters high-density lipoprotein composition in vivo

European Journal of Biochemistry
J J ApostolopoulosG J Howlett

Abstract

The effects of altered serum 3,3',5-triiodothyronine levels on rat lipoprotein metabolism were examined. Daily injections of the hormone (50 micrograms/100 g body mass) over a period of six days led to an increase of 6.4-fold in the hepatic mRNA level for apolipoprotein(apo)A-I, and a 21% increase in serum apoA-I levels. 12h after a single injection of 3,3',5-triiodothyronine the rate of [14C]leucine incorporation into apoA-I increased 2.1 fold. Conversely, in hypothyroid rats there was a decrease in hepatic mRNA levels for apoA-I and a decreased rate of [14C]leucine incorporation into apoA-I. The increase in hepatic apoA-I mRNA levels following 3,3',5-triiodothyronine treatment occurred prior to significant changes in serum triacylglycerol levels. High-density lipoprotein (HDL) particles isolated from the serum of hyperthyroid rats were smaller and enriched in apoA-I compared to apoA-IV and apoE. Similar changes in HDL composition were observed following in vitro incubations of normal rat serum with purified rat apoA-I. The results suggest that during altered thyroid status, changes in serum HDL size and composition occur in association with significant changes in apoA-I gene expression.

References

Mar 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A G LackoL A Soloff
Aug 15, 1988·Biochemical and Biophysical Research Communications·J J ApostolopoulosG J Howlett
Jan 1, 1986·Methods in Enzymology·V N Schumaker, D L Puppione
Apr 1, 1985·Metabolism: Clinical and Experimental·E MulsP De Moor
Oct 10, 1968·Analytical Biochemistry·R S Basch
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Aug 1, 1980·Metabolism: Clinical and Experimental·T Murase, H Uchimura

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Citations

Aug 17, 2006·Journal of Basic and Clinical Physiology and Pharmacology·Ramasamy Subramanian Vijayakumar, Namasivayamin Nalini
Jan 5, 2011·Biochimica Et Biophysica Acta·Camilla PramfalkPaolo Parini
Sep 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J BlangeroJ W MacCluer
Jul 1, 1995·European Journal of Biochemistry·Y VandenbrouckM Mangeney-Andreani
Jan 1, 1996·Life Sciences·B Leininger-Muller, G Siest
Apr 23, 1992·Biochimica Et Biophysica Acta·Y C HaG J Howlett

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