Triiodothyronine modulates growth, secretory function and androgen receptor concentration in the prostatic carcinoma cell line LNCaP

Molecular and Cellular Endocrinology
M EsquenetG Verhoeven

Abstract

There is increasing evidence that the course of prostatic carcinoma is determined by a complex interplay between genetic events, paracrine interactions, and hormonal and dietary factors. These latter factors include several ligands of the nuclear receptor family such as androgens, vitamin D3 and retinoids. To test whether thyroid hormones also influence the growth and differentiated function of prostatic carcinoma cells, LNCaP cells were treated with or without triiodothyronine (T3) in the absence or in the presence of other regulatory factors. Exposure of LNCaP cells to T3 for 6 days in the absence of androgens caused a dose-dependent increase in [3H]-thymidine incorporation with a maximal stimulation of 2.5-fold at 10(-9) M T3. Secretion of prostate-specific antigen (PSA) was also stimulated 2-3-fold. The observed effects may well be mediated by a nuclear T3 receptor as evidenced by displaceable T3 binding studies. Combined treatment of LNCaP cells with androgens and T3 revealed intriguing interactions between these two pathways. Below and up to 10(-10) M of the synthetic androgen R1881, the concentration that evokes optimal proliferative responses, T3 stimulated [3H] thymidine incorporation. At higher concentrations of andro...Continue Reading

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Citations

Mar 24, 1998·Molecular and Cellular Endocrinology·M EsquenetG Verhoeven
Apr 25, 2009·IUBMB Life·Celine J Guigon, Sheue-yann Cheng
Aug 3, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J JanosekI Holoubek
May 27, 2014·Frontiers in Physiology·Wei-Lin W Wang, Martin Tenniswood
May 6, 2008·The Prostate·Håkon RambergKristin Austlid Taskén
Dec 25, 2009·The Prostate·Michael Maria AruldhasVenkatesh Nagamangalam Seshadri
Mar 2, 2016·Molecular Medicine·Evangelina Delgado-GonzálezBrenda Anguiano
Nov 1, 2006·Expert Review of Endocrinology & Metabolism·Paul J DavisMichael J Ciesielski
Sep 21, 2016·The Journal of Clinical Endocrinology and Metabolism·Samer R KhanRobin P Peeters

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