Triiodothyronine-predominant Graves' disease in childhood: detection and therapeutic implications

European Journal of Endocrinology
Julie HarvengtJuliane Léger

Abstract

To assess in a pediatric population, the clinical characteristics and management of triiodothyronine-predominant Graves' disease (T3-P-GD), a rare condition well known in adults, but not previously described in children. We conducted a university hospital-based observational study. All patients with GD followed for more than 1 year between 2003 and 2013 (n=60) were included. T3-P-GD (group I) was defined as high free T3 (fT3) concentration (>8.0 pmol/l) associated with a normal free thyroxine (fT4) concentration and undetectable TSH more than 1 month after the initiation of antithyroid drug (ATD) treatment. Group II contained patients with classical GD without T3-P-GD. Eight (13%) of the patients were found to have T3-P-GD, a median of 6.3 (3.0-10.5) months after initial diagnosis (n=4) or 2.8 (2.0-11.9) months after the first relapse after treatment discontinuation (n=4). At GD diagnosis, group I patients were more likely to be younger (6.8 (4.3-11.0) vs 10.7 (7.2-13.7) years) and had more severe disease than group II patients, with higher serum TSH receptor autoantibodies (TRAb) levels: 40 (31-69) vs 17 (8-25) IU/l, P<0.04, and with slightly higher serum fT4 (92 (64-99) vs 63 (44-83) pmol/l) and fT3 (31 (30-46) vs 25 (17-31) ...Continue Reading

References

Dec 1, 1990·Pediatric Clinics of North America·D Zimmerman, M Gan-Gaisano
Jul 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J J Chen, P W Ladenson
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J I Hamburger
Mar 1, 1988·Journal of Endocrinological Investigation·D ReinweinA Schleusener
Nov 24, 2005·Acta Paediatrica·Raquel BarrioMilagros Alonso
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Peter LaurbergKlaus M Pedersen
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Hirotoshi NakamuraNoboru Hamada
Feb 13, 2008·Pediatrics·Nicole S GlaserUNKNOWN Organization of Pediatric Endocrinologists of Northern California Collaborative Graves' Disease Study Group
Jul 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Florentia KaguelidouUNKNOWN French Childhood Graves' Disease Study Group
Jun 10, 2009·Hormone Research·Florentia KaguelidouJuliane Léger
Jun 28, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rebecca S BahnUNKNOWN American Association of Clinical Endocrinologists
Sep 13, 2011·European Journal of Endocrinology·Mirna Abraham-NordlingGöran Wallin
Oct 28, 2011·The Journal of Clinical Endocrinology and Metabolism·Juliane LégerUNKNOWN French Childhood Graves' Disease Study Group
Mar 8, 2012·Lancet·Jayne A Franklyn, Kristien Boelaert
Oct 31, 2012·European Journal of Endocrinology·Chisa MatsumotoToru Takano
Mar 2, 2013·Clinical Endocrinology·Inge Bülow PedersenPeter Laurberg
Feb 13, 2014·The Journal of Pediatrics·Roberto GastaldiAndrea Corrias

❮ Previous
Next ❯

Citations

Nov 4, 2015·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Martín-FríasR Barrio Castellanos
Apr 7, 2017·European Journal of Endocrinology·Juliane Léger, Jean-Claude Carel
Aug 8, 2018·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Emi HamajimaMasayuki Kokaji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Florentia KaguelidouFrench Childhood Graves' Disease Study Group
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M SchottJ Seissler
© 2021 Meta ULC. All rights reserved