Triiodothyronine (T3) action on aquatic locomotor behavior during metamorphosis of the bullfrog Rana catesbeiana.

The International Journal of Developmental Biology
Marisabel Fernández-MongilLegier V Rojas

Abstract

Thyroid hormones--particularly triiodothyronine, T3--play a critical role in the morphological transformations comprising metamorphosis in larval bullfrogs (Rana catesbeiana). Traditional staging criteria for anuran larvae incompletely distinguish physiological and behavioral changes during growth. We therefore first developed a new parameter to describe larval growth, the developmental index (DI), which is simply the ratio between the tail length of the larva and its head diameter. Using the DI we were able to identify two distinct populations classifying the larvae during growth along a continuous linear scale with a cutoff value of DI at 2.8. Classification based on the DI, used in this study, proved an effective complement to existing classifications based on developmental staging into pre- or pro-metamorphic stages. Exposure to T3 in the water induced a rapid (beginning within 5 min) and significant decrease (approximately 20-40%) in locomotor activity, measured as total distance traversed and velocity. The largest decrease occurred in more developed larvae (DI<2.8). To determine correlated changes in the neuromuscular junctions during metamorphosis and apoptotic tail loss, miniature endplate currents from tail muscle were...Continue Reading

References

Aug 1, 1987·Endocrine Reviews·J H OppenheimerH C Freake
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·H HuangD D Brown
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·E M Callery, R P Elinson
Jun 9, 2000·Annual Review of Physiology·J Zhang, M A Lazar
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·A M SchreiberD D Brown
Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Y Okada, E Maeno
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·Paul J Davis, Faith B Davis
Sep 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Biswajit DasDonald D Brown
Feb 14, 2003·Journal of Neuroscience Research·Legier V RojasJosé A Lasalde-Dominicci
Dec 1, 2004·The Journal of Cell Biology·Nuttawut SaelimJames D Lechleiter
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Donald D BrownRejeanne Juste
Jan 18, 2006·Molecular and Cellular Endocrinology·Jamshed R Tata

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