Triiodothyronine (T3) stimulates food intake via enhanced hypothalamic AMP-activated kinase activity

Regulatory Peptides
Shinya IshiiShinichi Oikawa

Abstract

Thyroid hormone regulates food intake. We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA. AMP-activated kinase (AMPK) is a serine/threonine protein kinase that is activated when cellular energy is depleted. We hypothesized that T3 causes an increase in hypothalamic AMPK activity, which in turn contributes to the development of T3-induced hyperphagia. Rats that were given s.c. injections of T3 (4.5 nmol/kg) had increased food intake 2 h later without alterations in NPY and POMC mRNA levels, but with increased hypothalamic phosphorylated AMPK (169%) and phosphorylated acetyl-CoA carboxylase (194%). To determine the more chronic effects of T3, rats were given 6 daily s.c. injection of T3 or the vehicle. Food intake was significantly increased. Multiple T3 injections increased hypothalamic phosphorylated AMPK (278%) and phosphorylated acetyl-CoA carboxylase (335%) compared to the controls. Intracerebroventricular administration of compound C, an AMPK inhibitor, blocked the food intake induced by a single or multiple inj...Continue Reading

References

Jan 1, 1991·The Journal of Clinical Investigation·J H OppenheimerM P Thompson
Jan 1, 1989·Endocrine Research·P J DavisW D Lawrence
Mar 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G AbrahamM Apfelbaum
Oct 1, 1974·Archives of Biochemistry and Biophysics·C A Carlson, K H Kim
Jun 1, 1997·European Journal of Biochemistry·D G Hardie, D Carling
Mar 29, 2001·Journal of Molecular and Cellular Cardiology·Z Q SunW A Coetzee
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Nov 26, 2002·Endocrinology·Shinya IshiiShinichi Oikawa
Jan 27, 2004·The Journal of Biological Chemistry·Ulrika AnderssonCaroline J Small
Mar 30, 2007·Diabetes, Obesity & Metabolism·N M MartinS R Bloom

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Citations

Jun 21, 2011·Journal of Thyroid Research·Anjali AminKevin G Murphy
Nov 24, 2012·Nutrition Research Reviews·Andoni LanchaJavier Gómez-Ambrosi
Aug 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yen-Jui ChangShyi-Wu Wang
Oct 3, 2009·Biochimica Et Biophysica Acta·Pablo B Martínez de MorentinMiguel López
Nov 4, 2008·Trends in Molecular Medicine·Ricardo LageMiguel López
Sep 6, 2015·General and Comparative Endocrinology·J C WingfieldS L Meddle
May 7, 2009·Journal of Neurochemistry·Gabriele V RonnettSusan Aja
Apr 28, 2011·Clinical Endocrinology·Leonidas H DuntasGeorg Brabant
Mar 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Kuliczkowska-PlaksejJ Jakubowska
May 6, 2014·Frontiers in Endocrinology·Carmen Sobrino CrespoEduardo Arilla Ferreiro
Aug 7, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Mohamed Babo FadlallaFangxiong Shi
Aug 16, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianxun Lei, David H Ingbar
Jul 13, 2018·International Journal of Molecular Sciences·Soumaya Kouidhi, Marie-Stéphanie Clerget-Froidevaux
Feb 6, 2021·Hormone Molecular Biology and Clinical Investigation·Mahmoud Ali KaykhaeiZahra Heidari
Nov 27, 2020·Frontiers in Endocrinology·Cole K Deal, Helene Volkoff
Apr 11, 2021·Experimental & Molecular Medicine·Eun-Seon YooJong-Woo Sohn
May 4, 2021·Frontiers in Neuroscience·Daniel J TorresMarla J Berry
Jun 29, 2021·General and Comparative Endocrinology·C LamberigtsJ Buyse
Dec 24, 2018·European Thyroid Journal·Zhi ZhangEric Fliers

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