PMID: 12780516Jun 5, 2003Paper

Trileaflet valve for VAD use with purged sinus

Artificial Organs
L GoubergritsKlaus Affeld

Abstract

Clinical applications of ventricle assist devices continue to be problematic due to thromboembolic complications. The problem originates mainly at the valves, which are usually made of an antithrombogenic material, such as cross-linked bovine pericardium. However, wherever the blood flow is stagnant or forms a recirculation region, a thrombus is likely to form. A similar blood flow is found in the space between the housing of the valve and the leaflets, the so-called valve sinus. Consequently, thrombi are often generated in this region. The novel valve design presented in this article avoids the formation of stagnant flow in the valve sinus during systole by a purge flow. This flow is taken from the main flow through the valve and is directed into each sinus region. The effect is achieved by perforation of the valve sinus with a small orifice at the bottom of the sinus. The purge flow effect is investigated with the computational fluid dynamics (CFD) method. The simulation shows that the purge flow effectively increases flow in the valve sinuses.

References

Jul 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·C SturmN H Hwang
Jan 1, 1982·Journal of Biomechanics·A A van SteenhovenR S Reneman
Nov 6, 1998·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·K AffeldO Holberndt
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
May 1, 1996·Artificial Organs·Victor L Poirier

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Citations

Apr 16, 2004·Artificial Organs·Paul S Malchesky
Dec 20, 2012·Expert Review of Medical Devices·Thomas E ClaiborneDanny Bluestein
Aug 4, 2007·The International Journal of Artificial Organs·R KaminskyP Verdonck

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