Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lingjie WangNing Chen

Abstract

During the expansion of aging population, the study correlated with brain aging is one of the important research topics. Developing novel and effective strategies for delaying brain aging is highly desired. Brain aging is characteristics of impaired cognitive capacity due to dysfunctional autophagy regulated by Rheb-mTOR signal pathway in hippocampal tissues. In the present study, we have established a rat model with brain aging through subcutaneous injection of D-galactose (D-gal). Upon the intervention of Trillium tschonoskii Maxim (TTM) saponin, one of bioactive components from local natural herbs in China, the learning and memory capacity of D-gal-induced aging rats was evaluated through Morris water maze test, and the regulation of Rheb-mTOR signal pathway and functional status of autophagy in hippocampal tissues of D-gal-induced aging rats was explored by Western blot. TTM saponin revealed an obvious function to improve learning and memory capacity of D-gal-induced aging rats through up-regulating Rheb and down-regulating mTOR, thereby rescuing dysfunctional autophagy to execute anti-aging role. Meanwhile, this study confirmed the function of TTM saponin for preventing and treating brain aging, and provided a reference fo...Continue Reading

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Citations

Aug 4, 2018·International Journal of Molecular Sciences·Xian-Bing ChenFei-Jun Huang
Sep 21, 2019·Biogerontology·Khairunnuur Fairuz Azman, Rahimah Zakaria
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Bangrong CaiJiansheng Li
Aug 14, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jin-Feng TengAn-Guo Wu
Feb 5, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bing Han, Chengwei He
Nov 20, 2021·Frontiers in Cell and Developmental Biology·Feiling SongYanhua Li

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