Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters

Pharmacology & Therapeutics
Keiji KubaJosef M Penninger

Abstract

Angiotensin-converting enzyme (ACE) 2 is a homolog to the carboxypeptidase ACE, which generates angiotensin II, the main active peptide of renin-angiotensin system (RAS). After the cloning of ACE2 in 2000, three major ACE2 functions have been described so far. First ACE2 has emerged as a potent negative regulator of the RAS counterbalancing the multiple functions of ACE. By targeting angiotensin II ACE2 exhibits a protective role in the cardiovascular system and many other organs. Second ACE2 was identified as an essential receptor for the SARS coronavirus that causes severe acute lung failure. Downregulation of ACE2 strongly contributes to the pathogenesis of severe lung failure. Third, both ACE2 and its homologue Collectrin can associate with amino acid transporters and play essential role in the absorption of amino acids in the kidney and gut. In this review, we will discuss the multiple biological functions of ACE2.

References

Jul 1, 1992·Journal of Cellular Biochemistry·Y NozakiW L Epstein
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F SoubrierP Corvol
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·L D HudsonR J Maunder
Jul 9, 1998·Journal of Human Hypertension·M G NichollsM Agarwal
Oct 30, 1998·Biochemical and Biophysical Research Communications·K TatemotoM Fujino
Jan 30, 2002·The Journal of Biological Chemistry·Chad VickersPeter Tummino
Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Richard P MarshallGeoffrey J Laurent
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Silvina RaidenJorge R Geffner
Oct 3, 2002·Journal of the American Chemical Society·Natalie A DalesMichael A Patane
Dec 19, 2002·DNA Sequence : the Journal of DNA Sequencing and Mapping·Takami KomatsuKazuo Hanaoka
Feb 28, 2003·The Journal of Biological Chemistry·Lili HuangRobert C Ladner
Mar 8, 2003·Hypertension·Christos TikellisMark E Cooper
May 6, 2003·Science·Marco A MarraRachel L Roper
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Sep 12, 2003·Journal of Molecular and Cellular Cardiology·Mary DonoghueRoger E Breitbart
Mar 1, 1956·The Journal of Experimental Medicine·L T SKEGGSN P SHUMWAY
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Feb 3, 2004·The Journal of Biological Chemistry·Paul TowlerMichael W Pantoliano
Mar 25, 2004·Physiological Genomics·Robson A S SantosMichael Bader
Aug 3, 2004·Nature Genetics·Robert KletaAkio Koizumi
Nov 17, 2004·Protein and Peptide Letters·Edward T ParkinNigel M Hooper
Jan 11, 2005·Experimental Physiology·Michael J KatovichMohan K Raizada
Jun 14, 2005·Current Opinion in Immunology·Yu Lung Lau, J S Malik Peiris
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger

❮ Previous
Next ❯

Citations

Mar 7, 2013·Pflügers Archiv : European journal of physiology·Michael Bader
Jul 5, 2011·Endocrine·Isabelle Castan-LaurellPhilippe Valet
Aug 22, 2013·Microbes and Infection·Thomas Perlot, Josef M Penninger
Dec 14, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Syed K HaqueDaniel Batlle
Nov 2, 2013·The Journal of Clinical Investigation·Teruki SatoKeiji Kuba
Feb 9, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S CameloC Suguihara
Dec 31, 2014·International Journal of Molecular Sciences·Kaustav Majumder, Jianping Wu
Mar 24, 2012·Current Opinion in Virology·Denis Gerlier
Dec 3, 2014·Peptides·Simone Moreira de MacêdoSérgio Henrique Sousa Santos
Jul 11, 2012·Blood Pressure·Cuie GuangFranco Milani
Dec 24, 2014·Amino Acids·Raphael N Vuille-dit-BilleFrançois Verrey
Dec 9, 2014·Metabolism: Clinical and Experimental·Stella BernardiMerlin C Thomas
Aug 9, 2016·Journal of Clinical Laboratory Analysis·Yan-Hui WuHong Qiao
Apr 27, 2013·Molecular & Cellular Proteomics : MCP·Sebastian TancoPetra Van Damme
Apr 11, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luciana M A BorémSergio H S Santos
Apr 12, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Teruki Sato, Keiji Kuba
Nov 14, 2019·British Journal of Pharmacology·Y S Bakhle
Apr 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiantian YanGuoan Lin
Apr 9, 2020·International Journal of Clinical Practice·Richard Albert Stein
Mar 8, 2020·British Journal of Pharmacology·Y S Bakhle
May 14, 2020·Journal of Biomolecular Structure & Dynamics·Mohammad Mahdi Nejadi BabadaeiMojtaba Falahati
Jul 3, 2020·Japanese Journal of Infectious Diseases·Binchen WangYiyuan Cao
Jun 17, 2020·Journal of Obesity & Metabolic Syndrome·Soo LimBo Kyung Koo
May 29, 2020·Current Cardiology Reviews·Antonio Crisafulli, Pasquale Pagliaro
Jul 2, 2020·Journal of Inherited Metabolic Disease·Peter T Clayton
May 3, 2020·British Journal of Pharmacology·Steve P H AlexanderMichael Spedding
Jul 20, 2020·European Journal of Heart Failure·Zhi-Yao WeiYong-Jian Geng
Jul 19, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rafael FrancoGemma Navarro
Oct 19, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anna VaškůJindřich Spinar
Jan 13, 2019·International Journal of Molecular Sciences·Teruki SatoKeiji Kuba
May 12, 2020·Frontiers in Cardiovascular Medicine·Florian Zores, Mathieu E Rebeaud
Jul 15, 2020·Aging Medicine·Qiong ChenUNKNOWN National Center of Gerontology
Jul 21, 2020·Journal of Ovarian Research·Alex R Straughn, Sham S Kakar
Jul 15, 2020·Acta Physiologica·Jan-Hendrik B Hardenberg, Friedrich C Luft
Aug 28, 2020·Frontiers in Public Health·Jonathan KopelHemant Goyal
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Md Tanvir KabirLotfi Aleya

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
co-immunoprecipitation

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Circulation Journal : Official Journal of the Japanese Circulation Society
Keiji KubaJosef M Penninger
Circulation Journal : Official Journal of the Japanese Circulation Society
Yumiko ImaiJosef M Penninger
© 2021 Meta ULC. All rights reserved