TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.

Frontiers in Immunology
Zheng JinXun Zhu

Abstract

Sepsis is associated with bacterial invasion and inflammation and has a high mortality rate. Previous studies have demonstrated that tripartite motif 59 (TRIM59) was involved in NF-κB signaling and could promote phagocytosis of macrophages, but the role of TRIM59 in sepsis is still unknown. In our study, we found that TRIM59 was downregulated in lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages (BMDMs). In the cecal ligation and puncture (CLP) sepsis mice model, the mortality of Trim59 flox/flox Lyz-Cre (Trim59-cKO) mice was higher, the immune cell infiltration and damage of liver and lung were more severe, and bacteria burden was increased. We also found that TRIM59 altered the production of pro-inflammation cytokines, as well as macrophage phagocytosis ability. Further analysis indicated that NF-κB signal pathway and Fcγ receptors might be involved in these regulations. Our study demonstrated for the first time that TRIM59 protects mice from sepsis by regulating inflammation and phagocytosis in macrophages.

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Citations

Jan 14, 2021·Cell Biology International·Tingting WanYanbo Li
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Hong XieXiaodi Yang
Jun 15, 2021·International Immunopharmacology·Zheng Jin, Zhenhua Zhu
Sep 28, 2021·Frontiers in Immunology·Huan LiPingan Zhang

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Methods Mentioned

BETA
flow cytometry
FACS
bronchoalveolar lavage
transfection
ubiquitination

Software Mentioned

Elisa
ImageJ

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