PMID: 9418942Jan 7, 1998Paper

Trimellitic anhydride-sensitive mouse as an animal model for contact urticaria

Journal of Applied Toxicology : JAT
A I LauermaH I Maibach

Abstract

The respiratory allergen trimellitic anhydride (TMA) has been shown to induce IgE production and immediate ear swelling in mice sensitized to it. We studied whether TMA sensitivity could be used as an animal model for immunological contact urticaria. BALB/C mice were sensitized to TMA by topical applications. Groups of animals were pretreated on the ears with the glucocorticosteroid (GCS) betamethasone-17,21-dipropionate, the antihistamine (AH) diphenhydramine hydrochloride, the non-steroidal anti-inflammatory drug (NSAID) indomethacin or vehicle (VEH). Ears were challenged with TMA and ear thickness was measured at baseline and 1, 2, 4, 8 and 24 h after challenge. Trimellitic anhydride caused a significant biphasic ear swelling response with an early peak at 1-2 h, a plateau at 4 h and a late peak at 24 h. However, there was also an early swelling by TMA in non-sensitized mice, suggesting that non-immunological as well as immunological mechanisms contribute to early swelling by TMA. Glucocorticosteroid suppressed significantly the early and to some extent the late TMA responses, while AH suppressed only early and NSAID only late TMA responses. Ear swelling in TMA-sensitive BALB/C mice may represent a combination of immunologic...Continue Reading

Citations

Apr 8, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tomoko MatsudaYasuyuki Imai
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arndt J SchotteliusJohn F Parkinson

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