Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd3 N@C80 : A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation

ACS Applied Materials & Interfaces
Tinghui LiXudong Li

Abstract

Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-Gd3N@C80, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-Gd3N@C80 more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-Gd3N@C80 also suppressed LPS-elicited mRNA expression of pro-inflammatory inducible nitric oxide synthase and tumor necrosis factor-alpha, and upregulated antioxidative enzyme axis Nrf2 and heme oxygenase-1, possibly via ERK but not AKT signaling pathways. Therefore, carboxyl-Gd3N@C80 held a great promise in becoming a novel theranostic nanoplatform for simultaneously deliver MRI contrast and therapeutic functions to inflammation-related diseases.

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Citations

Dec 21, 2019·Nanoscale·Roger M Pallares, Rebecca J Abergel
Jan 12, 2021·Advanced Drug Delivery Reviews·Jun ChenHo-Wook Jun
Oct 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xubiao WeiManyi Zhang
Jun 27, 2020·Journal of the American Chemical Society·Olesya SemivrazhskayaYoko Yamakoshi
Jul 4, 2019·Journal of the American Chemical Society·Olesya SemivrazhskayaYoko Yamakoshi

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