Trimetazidine: is it a promising drug for use in steatotic grafts?

World Journal of Gastroenterology : WJG
Ismail Ben MosbahC Peralta

Abstract

Chronic organ-donor shortage has led to the acceptance of steatotic livers for transplantation, despite the higher risk of graft dysfunction or nonfunction associated with the ischemic preservation period of these organs. The present study evaluates the effects of trimetazidine (TMZ) on an isolated perfused liver model. Steatotic and non-steatotic livers were preserved for 24 h in the University of Wisconsin (UW) solution with or without TMZ. Hepatic injury and function (transaminases, bile production and sulfobromophthalein (BSP) clearance) and factors potentially involved in the susceptibility of steatotic livers to ischemia-reperfusion (I/R) injury, including oxidative stress, mitochondrial damage, microcirculatory diseases, and ATP depletion were evaluated. Steatotic livers preserved in UW solution showed higher transaminase levels, lower bile production and BSP clearance compared with non-steatotic livers. Alterations in perfusion flow rate and vascular resistance, mitochondrial damage, and reduced ATP content were more evident in steatotic livers. TMZ addition to UW solution reduced hepatic injury and ameliorated hepatic functionality in both types of the liver and protected against the mechanisms potentially responsible ...Continue Reading

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Citations

Feb 28, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ismail Ben MosbahCarmen Peralta
Sep 8, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Amine ZaoualiCarmen Peralta
Nov 27, 2010·Journal of Pineal Research·Mohamed Amine ZaoualíJoan Rosello-Catafau
Feb 17, 2015·World Journal of Gastroenterology : WJG·Eirini PantaziJoan Roselló-Catafau
Jan 17, 2015·World Journal of Gastroenterology : WJG·Mohamed BejaouiJoan Roselló-Catafau
May 7, 2019·World Journal of Gastrointestinal Surgery·Konstantin Y Tchilikidi
Nov 5, 2015·Canadian Journal of Physiology and Pharmacology·Hayam AteyyaManar A Nader
Mar 12, 2017·International Journal of Molecular Sciences·Mohamed Amine ZaoualiJoan Roselló-Catafau
Feb 19, 2010·Expert Opinion on Pharmacotherapy·Mohamed Amine ZaoualiJoan Roselló-Catafau
May 30, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Chengfu XuYouming Li
Oct 26, 2010·Transplantation Proceedings·M A ZaoualiJ Roselló-Catafau

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