PMID: 4885025Mar 1, 1969Paper

Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital

British Medical Journal
D S ReevesW Brumfitt

Abstract

Trimethoprim is inhibitory for a wide range of bacteria, and when used in combination with a sulphonamide marked synergy has been reported.In order to test its value in the treatment of urinary infections 154 hospital patients with infections of varying severity and due to a wide range of organisms were treated with combinations of sulphamethoxazole and trimethoprim. Combinations of these substances in two different ratios (2:1 and 10:1) were used in 113 patients, and one week after the end of treatment about three-quarters were cured by both combinations. In a second study 106 patients were treated with a sulphamethoxazole-trimethoprim combination (5:1), ampicillin, or sulphadimidine. The cure rate with the 5:1 combination was higher than that found with ampicillin or sulphadimidine both one week after finishing treatment (sulphamethoxazole-trimethoprim 85%, ampicillin 70%, sulphadimidine 40%) and at the fourth- to fifth-week follow-up (sulphamethoxazole-trimethoprim 67%, ampicillin 52%, sulphadimidine 15%).The results obtained with the various sulphamethoxazole-trimethoprim combinations did not indicate that a particular ratio was superior for treating urinary infections in general or for those caused by any particular specie...Continue Reading

References

Sep 27, 1967·Annals of the New York Academy of Sciences·W Brumfitt, A Percival
Sep 1, 1967·The British Journal of Venereal Diseases·G W Csonka, G J Knight
Mar 1, 1968·Journal of Clinical Pathology·J H DarrellP M Waterworth
Nov 1, 1962·Journal of Medicinal and Pharmaceutical Chemistry·B ROTHS R BUSHBY

❮ Previous
Next ❯

Citations

Jun 1, 1983·European Journal of Clinical Microbiology·J G GuerraE Antunez de Mayolo
Dec 1, 1975·Indian Journal of Pediatrics·H SaxenaM Sharma
Sep 19, 1974·The New England Journal of Medicine·G K Harding, A R Ronald
Feb 1, 1970·British Journal of Urology·D S Reeves, M Ghilchik
Apr 1, 1972·British Journal of Urology·R R Bailey, K G Koutsaimanis
Aug 1, 1972·Archives of Disease in Childhood·E M Poskitt, J M Parkin
Mar 18, 1972·British Medical Journal·M P FlemingR N Grüneberg
May 24, 1969·British Medical Journal·R N MorzariaD Pickering
Aug 8, 1970·British Medical Journal·Z FaridS E Hathout
Sep 11, 1971·British Medical Journal·B Hulme, D S Reeves
Oct 5, 1974·British Medical Journal·C L Hall
Jul 1, 1970·Journal of Clinical Pathology·W A Black, D A McNellis
Jul 1, 1971·Journal of Clinical Pathology·D S Reeves
Jun 1, 1972·Journal of Clinical Pathology·B Chattopadhyay
Jan 1, 1975·Scandinavian Journal of Infectious Diseases·B AllingA Svanborg
Jan 1, 1974·Scandinavian Journal of Infectious Diseases·A KasanenS Aantaa
Jan 1, 1973·Scandinavian Journal of Urology and Nephrology·S T Madsen
Dec 1, 1970·Scandinavian Journal of Infectious Diseases·H Laursen, M L Nielsen
Jan 1, 1969·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Seah, P D Marsden
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·H V SardesaiA B Diwate
May 1, 1970·The British Journal of Dermatology·J S Strauss, P E Pochi
May 1, 1974·The Journal of Urology·M D Cosgrove, J W Morrow
Mar 1, 1969·Scottish Medical Journal
Jun 1, 1972·Developmental Medicine and Child Neurology·M Thomas, J M Hopkins
Jan 16, 1971·The Medical Journal of Australia·L P Roy
Mar 6, 1971·The Medical Journal of Australia·B C Stratford, S Dixson
Mar 27, 1971·The Medical Journal of Australia·R A Evans, R E Benson
Jun 1, 1981·Microbiological Reviews·A L Koch
Jun 30, 1973·The Medical Journal of Australia·W Brumfitt, R Pursell
Aug 17, 2021·Frontiers in Microbiology·Hongmei ShiJiao-Yu Deng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Pathology
J H DarrellP M Waterworth
British Medical Journal
O O AkinkugbeO A Okubadejo
British Medical Journal
D J Wright, A Grimble
© 2021 Meta ULC. All rights reserved