PMID: 6981164Mar 1, 1982Paper

Trimethoprim-sulfamethoxazole and trimethoprim alone in the prophylaxis of childhood urinary tract infection

Reviews of Infectious Diseases
J M SmellieH M Bantock

Abstract

In 1975 trimethoprim-sulfamethoxazole (TMP-SMZ) was found effective in the prophylaxis of childhood urinary tract infection. The rate of recurrence in 130 children who received prophylaxis was only 0.05 infections per year. No fecal coliforms were found in 70% of rectal swabs, and only 10% of the isolates of coliform organisms were resistant to TMP. During effective, low-dose urinary prophylaxis with TMP-SMZ in 130 children for periods of two to 10 years, no effects of the drug on hematologic or renal function were observed, and somatic growth was normal. However, the frequency of resistance to TMP among fecal coliforms increased from less than 10% in 1970-1975 to 34% in 1980. This increase was not related to the duration of prophylaxis and appeared to represent a secular increase in TMP resistance among coliforms. TMP alone also was effective in urinary prophylaxis; only three of 39 children experienced a recurrence of urinary tract infection during a total of 309 months of prophylaxis in 1978-1980. The effect of TMP prophylaxis on the bowel flora was similar to that of TMP-SMZ prophylaxis. Resistance to TMP was found in 16% of isolates from rectal swabs from children receiving TMP alone.

Citations

Sep 1, 1983·European Journal of Pediatrics·J M SmellieA M Paton
Jan 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J M SmellieN Prescod
Apr 19, 2008·Current Urology Reports·Sherry Sedberry-Ross, Hans G Pohl
Oct 1, 1985·Postgraduate Medical Journal·J M Smellie, I C Normand
May 27, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Seung-Hun Song, Kun Suk Kim
Oct 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R Beetz
Feb 14, 2007·The Journal of Urology·Seung-Hun SongKun Suk Kim
Jul 13, 2004·The Journal of Urology·Edward Karpman, Eric A Kurzrock
Aug 19, 2010·Annals of Saudi Medicine·Aftab S ChishtiStefan G Kiessling

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