PMID: 6966331Jun 1, 1980Paper

Trimethoprim-sulfamethoxazole compared with ampicillin in the treatment of acute otitis media

The Journal of Pediatrics
P A ShurinJ O Klein

Abstract

We treated 132 children with acute otitis media in a randomized trial comparing trimethoprim-sulfamethoxazole and ampicillin. The antibacterial efficacy of the drugs was assessed primarly from the results of cultures of middle ear aspirates obtained during or after the course of therapy; persistent, recurrent, and new infections of the middle ear were documented in both groups of patients but did not differ significantly. Both drug regimens were well accepted by the patients and were not associated with serious side effects or toxicity. TMP-SMZ is an effective alternate to AMP or to other accepted regimens for initial treatment of acute otitis media.

References

Jun 1, 1978·The Journal of Pediatrics·P A ShurinJ O Klein
Sep 30, 1978·British Medical Journal·A J Howard, J D Williams
Dec 1, 1977·Antimicrobial Agents and Chemotherapy·S I PeltonM Finland
May 17, 1979·The New England Journal of Medicine·P A ShurinJ O Klein
Feb 24, 1977·The New England Journal of Medicine·P A ShurinJ Finkelstein
Aug 12, 1972·British Medical Journal·J R May, J Davies
Nov 1, 1973·The Journal of Infectious Diseases·J J Burchall
Nov 1, 1973·The Journal of Infectious Diseases·G H Hitchings
Aug 1, 1974·Journal of Pharmaceutical Sciences·C W SigelG H Hitchings

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Citations

Mar 1, 1986·Indian Journal of Pediatrics·S M Merchant, N P Vithlani
Jun 1, 1992·Clinical Otolaryngology and Allied Sciences·J Q ClaessenG J Hordijk
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·R de GrootA L Smith
Apr 11, 2008·International Journal of Pediatric Otorhinolaryngology·Michael E Pichichero, Janet R Casey
Aug 2, 2002·Expert Opinion on Pharmacotherapy·Michael E Pichichero, Janet R Casey
Jul 1, 1991·The Journal of Pediatrics·C E JohnsonP A Shurin
Mar 1, 1983·Pediatric Annals·S I Pelton, P Whitley
Aug 1, 1988·The Journal of Laryngology and Otology·M J BelliniR M Terry
May 1, 1982·Drug Intelligence & Clinical Pharmacy·J D GaskinsJ Ward
Oct 22, 2003·The Pediatric Infectious Disease Journal·Stephen I Pelton
May 1, 1981·The Annals of Otology, Rhinology & Laryngology. Supplement·J O Klein

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