Trimethoprim-sulfamethoxazole prophylaxis in the management of chronic granulomatous disease

The Journal of Infectious Diseases
D M MargolisJ I Gallin

Abstract

Long-term oral antimicrobial prophylaxis is accepted practice in the management of patients with chronic granulomatous disease (CGD). Reports of adverse outcome with trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis in other patient groups, and the recent occurrence of several severe fungal infections in patients followed at the National Institutes of Health (NIH), prompted a review of the NIH experience to examine the incidence of nonfungal and fungal infections in CGD patients with and without TMP-SMX prophylaxis. Prophylaxis decreased the incidence of nonfungal infections from 7.1 to 2.4 per 100 patient-months in patients with autosomal CGD (P less than .01) and from 15.8 to 6.9 infections per 100 patient-months (P = .06) in X-linked CGD patients. There was no significant change in the incidence of fungal infection in CGD patients on TMP-SMX (1.5-0.3 fungal infections/100 patient-months in autosomal CGD and 1.7-0.2 fungal infections/100 patient-months in X-linked CGD patients). TMP-SMX prophylaxis is indicated for the management of patients with CGD and decreases the incidence of non-fungal infections without increasing the incidence of fungal infections.

Citations

Jun 10, 1998·Springer Seminars in Immunopathology·C Meischl, D Roos
Nov 1, 1993·European Journal of Pediatrics·A FischerR S Weening
Feb 6, 2010·Pediatric Radiology·Alexander J Towbin, Ian Chaves
Jun 9, 2009·Clinical Reviews in Allergy & Immunology·Steven M Holland
Oct 21, 1994·Biochimica Et Biophysica Acta·A J ThrasherA W Segal
Sep 3, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Srinivasan RamanujaRobert P Nelson
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeannie S HuangJohn Bastian
Nov 21, 1991·The New England Journal of Medicine·R MouyA Fischer
Dec 7, 2000·The New England Journal of Medicine·J A Lekstrom-Himes, J I Gallin
Jun 13, 2003·The New England Journal of Medicine·John I GallinSteven M Holland
Dec 31, 2010·The New England Journal of Medicine·Douglas B KuhnsJohn I Gallin
Aug 23, 2005·Medical Mycology·N G AlmyroudisB H Segal
Jul 30, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan E DormanSteven M Holland
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brahm H SegalSteven M Holland
Jan 29, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M L GalluzzoS D Rosenzweig
Nov 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophie BlumentalAlain Fischer
Apr 16, 1998·The Pediatric Infectious Disease Journal·D Kosmala, D Janner
Jun 3, 1999·The Pediatric Infectious Disease Journal·H Narchi, S Gammoh
Dec 6, 2001·The Pediatric Infectious Disease Journal·K D Yang, H R Hill
Jan 6, 2006·The Pediatric Infectious Disease Journal·Jessica S KosutBarbara A Jantausch
Mar 18, 2011·The Pediatric Infectious Disease Journal·Alexandra F FreemanSteven M Holland
Apr 1, 1994·Immunological Reviews·D Roos
Mar 29, 2001·Journal of Clinical Pathology·R Lakshman, A Finn
Mar 19, 2013·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Arthur G ChungAnne K Ellis
May 21, 2011·Orphanet Journal of Rare Diseases·Jean DonadieuChristine Bellanné Chantelot
Mar 27, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Saleh Z Al-Muhsen
Jan 27, 1996·Lancet·J G LieseB H Belohradsky
Aug 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claire AguilarOlivier Lortholary
May 30, 2008·Seminars in Immunopathology·Marie José Stasia, Xing Jun Li
Jun 7, 2007·European Journal of Pediatrics·Charalampos AntachopoulosEmmanuel Roilides
Oct 4, 2012·Expert Review of Anti-infective Therapy·Josef Ben-AriBaruch Wolach
Mar 17, 2015·Expert Review of Anti-infective Therapy·Vikas GautamAmit Agarwal
Feb 9, 2013·Expert Review of Clinical Immunology·Seyed Alireza MahdavianiAli Akbar Velayati
Jan 1, 2009·Expert Review of Clinical Immunology·Sergio D Rosenzweig
Aug 21, 2015·Expert Review of Clinical Immunology·Payam MohammadinejadAsghar Aghamohammadi
Nov 24, 2007·Expert Opinion on Biological Therapy·Martin F RyserSebastian Brenner
Feb 13, 2016·Indian Journal of Pediatrics·Amit RawatSurjit Singh
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Merin Kuruvilla, Maria Teresa de la Morena
Nov 8, 2008·Chest·Lancelot Mark Pinto, Zarir Farokh Udwadia
Mar 19, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shradha Agarwal, Lloyd Mayer
Jan 29, 2013·Hematology/oncology Clinics of North America·Steven M Holland

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