PMID: 6981176Mar 1, 1982Paper

Trimethoprim-sulfamethoxazole therapy for Pneumocystis carinii pneumonitis in children

Reviews of Infectious Diseases
W T Hughes

Abstract

Trimethoprim-sulfamethoxazole (TMP-SMZ) is effective in both the treatment and the prevention of Pneumocystis carinii pneumonitis. After initial evaluation in an animal model, TMP-SMZ was shown to be as clinically effective as pentamidine isethionate for the treatment of pneumonitis in children with cancer and to have minimal adverse effects. Treatment with TMP-SMZ (20 mg of TMP and 100 mg of SMZ per kg of body weight per day) was successful in three-fourths of patients tested. Administered prophylactically, TMP-SMZ (5.0 mg of TMP and 25 mg of SMZ per kg of body weight per day) prevented P. carinii infection in high-risk immunocompromised patients. Studies of the unstructured delivery of prophylactic TMP-SMZ have demonstrated the regimen to be feasible and effective, with a favorable benefit-risk ratio for a large number of children with cancer.

Citations

Jan 27, 2015·The Lancet Infectious Diseases·James A ChurchAndrew J Prendergast
Dec 4, 2014·The Lancet Infectious Diseases·Miguel F CarrascosaJavier Gómez Román
Sep 1, 1996·The Journal of Eukaryotic Microbiology·C CreusyE Dei-Cas
Dec 1, 1985·Antimicrobial Agents and Chemotherapy·M T CushionP D Walzer

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