PMID: 6981157Mar 1, 1982Paper

Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae

Reviews of Infectious Diseases
D T DurackJ R Perfect

Abstract

When given in combination, both trimethoprim and sulfamethoxazole penetrated well into the cerebrospinal fluid of rabbits with experimental pneumococcal meningitis, reaching concentrations that should have been adequate for synergistic killing of Streptococcus pneumoniae. However, trimethoprim-sulfamethoxazole was less effective than ampicillin in the treatment of this experimental infection. The effect of the combination on pneumococci in vivo was bacteriostatic rather than bactericidal, possibly because the number of pneumococci in the cerebrospinal fluid of the rabbits at the start of treatment was larger than that in the inoculum used for in vitro sensitivity tests.

Citations

Dec 1, 1984·European Journal of Clinical Microbiology·W M Scheld
Dec 1, 1996·Free Radical Research·A von HerbayH Sies
Sep 11, 1986·The New England Journal of Medicine·C Van der Straeten, J H Klippel
Jun 1, 1995·Annals of Tropical Medicine and Parasitology·G O OyeyinkaJ R Idowu

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