PMID: 9184713Jun 1, 1997Paper

Trimethoprim/sulfamethoxazole-induced hypoglycemia in a patient with acute renal failure

The Annals of Pharmacotherapy
A J Lee, D S Maddix

Abstract

To report a case of trimethoprim/sulfamethoxazole (TMP/SMX)-induced hypoglycemia in a patient with acute renal failure. English-language references identified via a MEDLINE search from January 1966 to August 1996 and a bibliographic review of pertinent articles. Similar to sulfonylureas, sulfonamides are thought to cause hypoglycemia by increasing pancreatic secretion of insulin. To date, nine cases of TMP/SMX-induced hypoglycemia have been reported in the literature. This case represents the second report in which a patient experienced TMP/SMX-induced hypoglycemia that resolved after the dosage was adjusted for the patient's decreased renal function. This case involved a 73-year-old comatose white man initiated on high-dose TMP/SMX for nosocomial pneumonia caused by Stenotrophomonas maltophilia. After 5 days of therapy, the patient presented with severe hypoglycemia that persisted over 8 hours despite multiple intravenous bolus doses and infusions of dextrose. The patient had several risk factors that may have compounded his risk for hypoglycemia, including food deprivation and acute renal failure. After management with dextrose and dose adjustment of the patient's TMP/SMX regimen according to renal function, the hypoglycemia ...Continue Reading

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Citations

Aug 27, 2005·Diabetes Care·Romana M HaasJames W Chu
Dec 22, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kaitlin E KennedyChristopher R Frei
Jan 13, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·J Kim, A D Mooradian
May 9, 2021·BMJ Case Reports·Jordan Kit MahStavroula Christopoulos
Sep 29, 1999·Endocrinology and Metabolism Clinics of North America·V Marks, J D Teale
Feb 28, 2006·The Lancet Infectious Diseases·Elizabeth L StrevelWayne L Gold
Aug 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Charles E LeonardSean Hennessy

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