PMID: 3745026Jan 1, 1986Paper

Trimethyltin ototoxicity: evidence for a cochlear site of injury

Hearing Research
L D FechterA L Nuttall

Abstract

The environmental contaminant, trimethyltin (TMT), produces a profound elevation in tone intensity necessary to inhibit the acoustic startle reflex in laboratory animals which recovers over a prolonged period except at very high frequencies. The recovery that is observed does not begin until 3 to 5 weeks after a single acute administration depending upon dosage. As opposed to the very temporary threshold shifts by the salicylates and loop diuretics or the permanent and progressive ototoxicity resulting from aminoglycoside antibiotics the time course for recovery of acoustic startle reflex inhibition after TMT appears to be an anomaly for a chemical ototoxicant. In terms of the duration of loss only, this pattern appears similar to that sometimes observed after noise exposure. The current investigation replicates the finding that recovery of acoustic startle reflex inhibition after TMT is frequency related in that only the highest frequency impairment appears to be permanent. While this frequency dependence suggests a cochlear locus of injury, both the known neurotoxic effects of TMT and the time course of the behavioral impairment suggest a more central locus of injury. Compound action potential and cochlear microphonic recordi...Continue Reading

References

Aug 1, 1975·Toxicology and Applied Pharmacology·R W FleischmanU Schaeppi
Feb 1, 1978·The Journal of the Acoustical Society of America·C A ProsenW C Stebbins
Aug 1, 1977·Journal of Comparative and Physiological Psychology·J B Kelly, B Masterton
Jul 1, 1988·The Journal of the Acoustical Society of America·L D FechterS Zeger
Jan 1, 1986·Toxicology and Applied Pharmacology·J S Young, L D Fechter
Jul 1, 1985·Toxicology and Applied Pharmacology·M F WuL W Lapham
Oct 1, 1973·The Laryngoscope·R ThalmannT Miyoshi
Sep 1, 1984·Bulletin of Environmental Contamination and Toxicology·L W Chang
Jan 1, 1983·Annals of the New York Academy of Sciences·P A Leake-Jones, S J Rebscher
May 1, 1983·The Journal of the Acoustical Society of America·J S Young, L D Fechter
Sep 15, 1983·Toxicology and Applied Pharmacology·L D Fechter, J S Young
Apr 1, 1983·Environmental Research·L W ChangD E McMillan

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Citations

Sep 1, 1987·Neurotoxicology and Teratology·C L EastmanL D Fechter
Sep 1, 1990·Neurotoxicology and Teratology·K M Crofton
Mar 1, 1991·Neurotoxicology and Teratology·V Hoeffding, L D Fechter
May 1, 1995·Neurotoxicology and Teratology·Y Liu, L D Fechter
Oct 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Y Liu, L D Fechter
Jun 15, 2004·Journal of Toxicology and Environmental Health. Part a·Laurence D Fechter
Aug 1, 1990·Toxicology and Applied Pharmacology·K M CroftonR Janssen
Nov 1, 1992·Human & Experimental Toxicology·E A Lock, E S Harpur
Apr 2, 2019·Journal of Cellular Physiology·Mansoureh SoleimaniFereshteh Azedi
Nov 1, 1989·Medical Toxicology and Adverse Drug Experience·M Y Huang, J Schacht
Jun 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·L P Rybak
Aug 1, 1990·Toxicology and Applied Pharmacology·L D Fechter, L Carlisle

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