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'Trim'ming PolyQ proteins with engineered PML

Biotechnology and Bioengineering

Nov 11, 2019

Neha DharRavi S. Kane

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Abstract

Protein abnormalities are the major cause of neurodegenerative diseases such as SCA (Spinocerebellar Ataxia). Protein misfolding and impaired degradation leads to the build-up of protein aggregates inside the cell, which may further cause cellular degeneration. Reducing levels of either...read more

Mentioned in this Paper

Mental Health
Nerve Degeneration
Ubiquitin-protein ligase
Ataxia, Spinocerebellar
Intracellular
Cytopathic Effect
Ataxin-1
Polyglutamine
Monomer
Sumoylation
1
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'Trim'ming PolyQ proteins with engineered PML

Biotechnology and Bioengineering

Nov 11, 2019

Neha DharRavi S. Kane

PMID: 31710088

DOI: 10.1002/bit.27220

Abstract

Protein abnormalities are the major cause of neurodegenerative diseases such as SCA (Spinocerebellar Ataxia). Protein misfolding and impaired degradation leads to the build-up of protein aggregates inside the cell, which may further cause cellular degeneration. Reducing levels of either...read more

Mentioned in this Paper

Mental Health
Nerve Degeneration
Ubiquitin-protein ligase
Ataxia, Spinocerebellar
Intracellular
1

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